AI Article Synopsis
- Adult neurogenesis is regulated by the balance between forming neurons and astrocytes from neural stem cells, and microRNAs (miRNAs) play a crucial role in this process.* -
- Researchers disabled Dicer, a key enzyme for miRNA production, in adult neural stem cells and found that miRNAs are necessary for producing new neurons, but not for creating astrocytes.* -
- The study identified 11 specific miRNAs that influence the fate of adult neural stem cells towards becoming neurons instead of astrocytes, suggesting they work together to support neurogenesis by targeting various pathways.*
Article Abstract
Adult neurogenesis requires the precise control of neuronal versus astrocyte lineage determination in neural stem cells. While microRNAs (miRNAs) are critically involved in this step during development, their actions in adult hippocampal neural stem cells (aNSCs) has been unclear. As entry point to address that question we chose DICER, an endoribonuclease essential for miRNA biogenesis and other RNAi-related processes. By specific ablation of Dicer in aNSCs in vivo and in vitro, we demonstrate that miRNAs are required for the generation of new neurons, but not astrocytes, in the adult murine hippocampus. Moreover, we identify 11 miRNAs, of which 9 have not been previously characterized in neurogenesis, that determine neurogenic lineage fate choice of aNSCs at the expense of astrogliogenesis. Finally, we propose that the 11 miRNAs sustain adult hippocampal neurogenesis through synergistic modulation of 26 putative targets from different pathways.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390108 | PMC |
| http://dx.doi.org/10.1016/j.stemcr.2017.02.012 | DOI Listing |
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