Purpose Of The Study: Driving is important for older adults' health and well-being, yet little research has examined interventions to maintain driving mobility. As fluid cognitive abilities are strongly linked to driving, targeted cognitive training interventions may impact driving mobility longitudinally. This study assessed the effects of three different cognitive training programs (reasoning, speed of processing, and memory) on driving cessation in older adults across 10 years (n = 2,390).
Design And Methods: Cox regression analyses evaluated the impact of each program relative to a no-contact control group with intent-to-treat (ITT) analyses. The effects of randomization to additional booster sessions were also examined. Subsample analyses repeated these models in participants who were at-risk for driving mobility declines.
Results: There were no training (n = 2,390) or booster training (n = 1,540) effects on driving cessation with ITT analyses. Individuals at-risk for future mobility declines were 49% (Hazard Ratio (HR) = 0.51, 95% confidence interval [CI]: 0.28, 0.94; n = 336) less likely to cease driving after speed of processing training and 55% (HR = 0.45, 95% CI: 0.24, 0.86; n = 324) less likely to quit driving subsequent to reasoning training. Additional booster sessions for speed of processing training resulted in a 70% reduction of driving cessation (HR = 0.30, 95% CI: 0.11, 0.82; n = 252) in the subsample analyses. There were no significant effects of memory training.
Implications: Some cognitive interventions transfer to maintained driving among those at-risk for mobility declines due to cognitive impairment. Future research should identify moderators and mediators of training and transfer effects.
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http://dx.doi.org/10.1093/geront/gnw143 | DOI Listing |
Int J Environ Res Public Health
December 2024
Tsurui Village Office, Tsurui 085-1203, Japan.
The percentage of older drivers is increasing worldwide. Older adults are driving for their daily lives, including drivers who should not drive, "must-watch drivers", for health conditions, etc. The "Public Survey of Long-Term Care Prevention and Needs in Spheres of Daily Life (Needs Survey)", including the " Checklist (KCL)", is a triennial nationwide survey conducted by welfare administrations in Japan.
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January 2025
Neuronal Circuits and Behavior Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224-6823, U.S.A.
The anterior hypothalamic area (AHA) is a key brain region for orchestrating defensive behaviors. Using in vivo calcium imaging in mice, we observed that AHA neuronal activity increases during foot shock delivery and foot-shock associated auditory cues. We found that following shock-induced increases in AHA activity, a decrease in activity coincides with the onset of grooming behavior.
View Article and Find Full Text PDFInt Breastfeed J
January 2025
Division of Epidemiology & Biostatistics, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, PO Box 241, Cape Town, 8000, South Africa.
Background: Despite efforts to promote optimal breastfeeding practices, the practice of exclusive breastfeeding is low in South Africa. We conducted a trial to determine whether text messaging plus motivational interviewing prolonged exclusive breastfeeding during the first six months of life and improved child health outcomes.
Methods: We conducted a randomized parallel group-controlled trial between July 2022 and May 2024, at a secondary-level healthcare facility.
Rural Ment Health
January 2025
Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida.
Driving cessation is robustly associated with poor mental health outcomes among older adults; however, the magnitude of this relationship may differ by rurality. This study examined cross-sectional and longitudinal associations between driving cessation and life satisfaction and depressive symptoms and assessed whether these relationships were moderated by rurality. Data is from participants in the 2014 and 2016 Health and Retirement Study (HRS) (mean age = 73; 58% female) with information on either depressive symptoms (n=5,650) or life satisfaction (n=1,931).
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
Alopecia areata (AA) is a prevalent autoimmune condition that causes sudden hair loss and poses significant psychological challenges to affected individuals. Current treatments, including corticosteroids and Janus kinase inhibitors, fail to provide long-term efficacy due to adverse effects and relapse after cessation. This study introduces a nanoparticle (NP) system that codeliver diphenylcyclopropenone (DPCP) and rapamycin (RAPA) prodrugs to induce immune tolerance and promote hair regeneration.
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