A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: Attempt to read property "Count" on bool

Filename: helpers/my_audit_helper.php

Line Number: 3100

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Characterization of HIV Seroconverters in a TDF/FTC PrEP Study: HPTN 067/ADAPT. | LitMetric

Characterization of HIV Seroconverters in a TDF/FTC PrEP Study: HPTN 067/ADAPT.

J Acquir Immune Defic Syndr

*Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ‡Department of Health Behavior and Health Education, School of Public Health, University of Michigan, Ann Arbor, MI; §Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD; ‖Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD; ¶Division of Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD; #Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO; **FHI 360, Durham, NC; ††Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; ‡‡Department of Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA; §§Departments of Medicine and Epidemiology, Columbia University Affiliation at Harlem Hospital, New York, NY; ‖‖Columbia University Mailman School of Public Health, New York, NY; ¶¶Department of Biostatistics, University of Washington, Seattle, WA; and ##University of California, San Francisco Gladstone Institutes, San Francisco, CA.

Published: July 2017

AI Article Synopsis

  • The HPTN 067/ADAPT trial tested tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) as pre-exposure prophylaxis (PrEP) for HIV prevention in women and men who have sex with men, focusing on different dosing schedules.
  • Out of 12 participants who seroconverted, many had low adherence to the PrEP regimen, with some being already infected before randomization or during the DOT phase.
  • Sensitive testing methods revealed HIV infections and drug resistance linked to inadequate PrEP exposure, indicating the importance of adherence for the effectiveness of PrEP.

Article Abstract

Background: HIV Prevention Trials Network (HPTN) 067/ADAPT evaluated tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) pre-exposure prophylaxis (PrEP) in women (South Africa) and men who have sex with men (Thailand, US). Participants received once-weekly directly observed therapy (DOT) of TDF/FTC, and were then randomized to daily, time-driven, or event-driven PrEP. This report describes characterization of 12 HIV seroconversion events in this trial.

Methods: HIV rapid testing was performed at study sites. Retrospective testing included fourth generation assays, HIV RNA testing, Western blot, an HIV-1/2 discriminatory assay, resistance testing, and antiretroviral drug testing.

Results: Six of the 12 seroconverters received TDF/FTC in the DOT phase, but were not randomized (3 were acutely infected at enrollment; 2 were infected during the DOT phase; 1 was not randomized because of pregnancy). One of the 6 randomized participants had acute infection at randomization but was not diagnosed for 3-4 months because HIV rapid tests were nonreactive; continued daily PrEP use was associated with false-negative antibody tests and low HIV RNA levels. The 5 participants infected after randomization included 4 with low adherence to the PrEP regimen, and one who reported a 7-day period without dosing before infection. Three participants had TDF/FTC resistance (M184I, K65R), including 2 who received only 4 once-weekly TDF/FTC doses; most TDF/FTC mutations were detected by next generation sequencing only.

Conclusions: In HPTN 067/ADAPT, participants who acquired HIV infection had infrequent PrEP dosing or low/suboptimal adherence. Sensitive assays improved detection of HIV infection and drug resistance. Drug resistance was observed with limited PrEP exposure.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472493PMC
http://dx.doi.org/10.1097/QAI.0000000000001374DOI Listing

Publication Analysis

Top Keywords

hptn 067/adapt
12
characterization hiv
8
hiv
8
received once-weekly
8
hiv rapid
8
hiv rna
8
dot phase
8
phase randomized
8
hiv infection
8
drug resistance
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: