Three new dentigerumycin analogues are produced by Streptomyces sp. M41, a bacterium isolated from a South African termite, Macrotermes natalensis. The structures of the complex nonribosomal peptide synthetase-polyketide synthase (NRPS/PKS) hybrid compounds were determined by 1D- and 2D-NMR spectroscopy, high-resolution mass spectrometry, and circular dichroism (CD) spectroscopy. Both cyclic and linear peptides are reported, and the genetic organization of the NRPS modules within the biosynthetic gene cluster accounts for the observed structural diversity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013059 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.7b00545 | DOI Listing |
Publication Analysis
Top Keywords
linear peptides
8
peptides major
4
major products
4
products biosynthetic
4
biosynthetic pathway
4
pathway encodes
4
encodes cyclic
4
cyclic depsipeptides
4
depsipeptides three
4
three dentigerumycin
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!