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Alkaline Phosphatase > 2000 U/L in an Infant With Stool Changes: A Case Report.
Perm J
September 2024
Department of Family Medicine, Loma Linda University, Loma Linda, CA, USA.
Article Synopsis
- Transient hyperphosphatasemia (TH) is a harmless condition noted in healthy young children, characterized by elevated alkaline phosphatase (ALP) levels, usually returning to normal within four months.* -
- A 12-month-old girl was identified with TH after presenting with some gastrointestinal symptoms and an elevated ALP level of 2379 IU/L; other serious conditions were considered but ruled out.* -
- The report highlights the importance of recognizing TH to prevent unnecessary medical tests, as it is typically managed through observation and monitoring ALP levels.*
Benign transient hyperphosphatasemia in the pediatric population: a single center cohort study.
J Pediatr Endocrinol Metab
July 2024
Department of Pediatric Endocrinology, Ankara Bilkent City Hospital, Ankara, Türkiye.
Objectives: Alkaline phosphatase (ALP) can be increased in a benign condition known as benign-transient hyperphosphatasemia (BTH). We aimed to evaluate the demographic, and clinical characteristics of infants and children with BTH.
Methods: In our retrospective study, infants and children diagnosed with BTH between September 2019 and September 2023 were included.
Transient hyperphosphatasemia in a toddler with COVID-19 infection: A case report and literature review.
World J Clin Pediatr
September 2023
Division of Endocrinology, Department of Pediatrics, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.
Background: Transient hyperphosphatasemia (TH) is a condition characterized by elevated serum alkaline phosphatase (ALP) in the clinical setting with no evidence of bone or liver disease among children under the age of 5. Typically, it will resolve spontaneously in a few months in the majority of cases. TH has been found to be associated with viral infections.
View Article and Find Full Text PDFBenign transient hyperphosphatasemia in infants and children: a retrospective database study.
Eur J Pediatr
July 2023
Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Unlabelled: Benign transient hyperphosphatasemia is a condition characterized by greatly increased serum alkaline phosphatase (ALP) without laboratory or clinical evidence of underlying bone or liver disease. It is usually identified incidentally during routine blood testing. We describe the demographic and clinical characteristics of benign transient hyperphosphatasemia in a cohort of healthy infants and children.
View Article and Find Full Text PDFRare case of benign transient hyperphosphatasemia in a complicated multiorgan adult transplant patient: Case report and literature review.
Clin Chim Acta
April 2023
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160, United States. Electronic address:
Background: Transient hyperphosphatasemia, characterized by isolated highly elevated alkaline phosphatase (ALP) activity in the absence of liver or bone disease, is typically seen in children but rarely in adults. Here we report highly elevated ALP activity in a complicated multiple-organ transplant patient due to benign transient hyperphosphatasemia.
Case Report: A 54-year-old male had a complicated past medical history including a bilateral lung transplant for cystic fibrosis in 2006, colonic resection due to colon cancer in December 2011 and subsequent chemotherapy which ended in June 2022.
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