Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour of the gastrointestinal tract composed of adenocarcinoma and neuroendocrine carcinoma. This pathologic diagnosis was recently defined by the WHO in 2010. The tumour may appear in various levels of the digestive tract including the oesophagus, stomach, colon and appendix. Biological behaviour of MANEC seems to be quite unpredictable and the prognosis uncertain. The disease may also mimic "simple" carcinoma. Only several tens of cases have been reported so far.Our first case was diagnosed as gastric adenocarcinoma mimicking early gastric cancer in a 47 years old male. The second case was diagnosed incidentally in the appendix of a 69 years old female after operation for gynaecologic cancer. The disease was localised in both patients; the patients underwent radical surgical resections.Treatment options have not been standardised yet, but aggressive therapeutic measures are recommended. The patients may benefit from multimodal anticancer therapy.Key words: mixed adenoneuroendocrine carcinoma - MANEC - gastric cancer - appendiceal cancer.
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Two cases of mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix: case report and review of the literature.
Diagn Pathol
December 2024
Department of Pathology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang Province, 321000, China.
Background: Mixed adenoneuroendocrine carcinoma (MANEC) of the cervix is a rare malignant tumor with high malignancy and poor prognosis, of which large-cell neuroendocrine carcinoma and HPV-independent adenocarcinoma are particularly rare, which have been reported limitedly in the literature. Here, we present 2 cases of MANEC of the cervix and discuss important considerations for diagnosing cervical poorly differentiated carcinoma.
Case Presentation: we reported two cases of mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix, one HPV-independent and one HPV-associated, both with vaginal bleeding.
Successful conversion surgery after comprehensive therapy in a patient with MSI-H but pMMR metastatic gastric mixed adenoneuroendocrine carcinoma: a case report and literature review.
Front Oncol
December 2024
Department of Gastroenterology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Gastric mixed adenoneuroendocrine carcinoma (MANEC) is a rare and highly aggressive malignancy characterized by both exocrine and neuroendocrine components. Treatment options for metastatic cases are limited, with typical therapeutic approaches involving a combination of chemotherapy and immunotherapy. A 68-year-old male with metastatic gastric MANEC was treated with targeted therapy, immunotherapy, and chemotherapy, including S-1, apatinib, cadonilimab, and paclitaxel.
View Article and Find Full Text PDFGastric Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm: An Unusual Tumor and Its Presentation in a Young Adult.
GE Port J Gastroenterol
December 2024
Department of Gastroenterology, Hospital de Braga, Braga, Portugal.
Article Synopsis
- Gastric cancer, primarily adenocarcinomas, is a leading cause of cancer death, and mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) is one of the rarest subtypes, with significant bleeding occurring in some patients.
- A case study involves a healthy 26-year-old male who had two major gastrointestinal bleeding episodes, leading to the discovery of a 15-mm lesion at the gastroesophageal junction, which was later diagnosed as a mixed adenoneuroendocrine carcinoma.
- Despite its rarity and the lack of established treatment protocols, the patient underwent surgery and chemotherapy, with no evidence of cancer recurrence two years later.
[Neuroendocrine carcinomas of the gastrointestinal tract : Morphology, molecular pathology, cellular origin].
Pathologie (Heidelb)
November 2024
Institut für Pathologie, Philipps-Universität Marburg und Universitätsklinikum Gießen und Marburg, Standort Marburg, Marburg, Deutschland.
Neuroendocrine carcinomas (NEC) are poorly differentiated neuroendocrine neoplasms that can occur ubiquitously in the mucosa-bearing organs of the gastrointestinal tract. Based on their morphology, they are classified into large cell (LCNEC) and small cell NEC (SCNEC). The most common form of mixed differentiation is the combination with an adenocarcinoma, referred to as mixed adenoneuroendocrine carcinoma (MANEC).
View Article and Find Full Text PDFMixed adenoneuroendocrine carcinomas of the appendix: Is there a survival advantage to right hemicolectomy over appendectomy?
Eur J Surg Oncol
January 2025
Department of General Surgery, Huzhou Central Hospital (The Affiliated Central Hospital of Huzhou University, The Fifth School of Clinical Medicine, Zhejiang Chinese Medical University, The Affiliated Huzhou Hospital, Zhejiang University School of Medicine), Huzhou, 313000, China. Electronic address:
Background: the surgical treatment and prognostic characteristics of mixed adenoneuroendocrine carcinomas (MANEC) of the appendix are not yet available. In this study, we sought to figure out the choice of surgical approach (right hemicolectomy versus appendectomy), and explore the effect of chemotherapy on appendiceal MANEC.
Methods: patients with appendiceal MANEC from the Surveillance, Epidemiology, and End Results database (2000-2020) were stratified by gender, race, age group, tumor grade, and TNM stage.
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