Purpose: Autologous matrix-induced chondrogenesis (AMIC) is a treatment for focal full-thickness cartilage defects combining microfracturing with an exogenous I/III collagen matrix (Chondro-Gide). The aim of the present study was to determine the 7 years outcomes of patients treated with the AMIC technique for knee chondral defects larger than 2 cm. The hypothesis was that the positive short-term outcomes achieved in the previous series would not deteriorate at a 7-year follow-up.
Methods: Twenty-one patients treated with the AMIC technique were retrospectively analysed. Patients were assessed through the IKDC subjective knee evaluation questionnaire and the Lysholm scoring system. All patients underwent a complete imaging study including radiographs and magnetic resonance. The median defect size was found to be 4.3 (range 2.9-8) cm.
Results: At a median follow-up of 7 (±1.4) years, the mean IKDC score improved from 31.7 (±8.9) points preoperatively, to 80.6 (±5.3) at the latest follow-up (p < 0.05). The mean Lysholm score improved from 38.8 (±12.4) points preoperatively to 72.6 (±19.5) points at the last follow-up (p < 0.05). At the last follow-up, 76.2% of patients were satisfied or extremely satisfied with their outcomes, while 66.6% of patients showed good quality repair tissue on magnetic resonance imaging.
Conclusion: AMIC was found to be an effective method to treat full-thickness knee chondral defects larger than 2 cm, with significant clinical and functional improvement maintained over a 7-year follow-up.
Level Of Evidence: IV.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00167-017-4503-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparison of autologous matrix-induced chondrogenesis and mosaicplasty in the treatment of osteochondral defects of the talus.
Acta Orthop Traumatol Turc
November 2024
Department of Orthopaedics and Traumatology, Acıbadem Eskişehir Hospital, Eskişehir, Türkiye.
Article Synopsis
- - The study compared the long-term effectiveness of two treatment methods, mosaicplasty and autologous matrix-induced chondrogenesis (AMIC), for osteochondral defects in the talus, evaluating 50 patients over a decade.
- - Both treatment groups showed significant improvements in functional scores post-surgery, though AMIC had slightly better outcomes; factors like age and gender did not impact effectiveness.
- - The researchers concluded that both methods are effective, but AMIC may offer superior results for similarly sized defects with less risk of complications compared to mosaicplasty.
Open-label, controlled, phase 2 clinical trial assessing the safety, efficacy, and pharmacokinetics of INM004 in pediatric patients with Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome.
Pediatr Nephrol
November 2024
Inmunova SA, Ciudad Autónoma de Buenos Aires, Argentina.
Background: Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is a severe condition mainly affecting children. It is one of the leading causes of acute kidney injury in the pediatric population. There is no established therapy for this disease.
View Article and Find Full Text PDFClinical and epidemiological characteristics of children with mosquito-borne diseases in a tertiary hospital, Buenos Aires, Argentina, 2023.
Arch Argent Pediatr
October 2024
Low Risk Sector; Pediatrics Hospital. S.A.M.I.C. Prof. Dr. Juan P. Garrahan, City of Buenos Aires, Argentina.
Introduction. Arboviruses, such as dengue and chikungunya, have caused multiple epidemics in the Americas. They are transmitted through mosquito bites; Aedes aegypti is their main vector.
View Article and Find Full Text PDFAMIC achieves sustained clinical improvement in isolated patellar cartilage defects over 5 years, correlating with MRI.
Knee Surg Sports Traumatol Arthrosc
October 2024
Universitat Autònoma de Barcelona, Departament de Cirurgia, Bellaterra, Spain.
Purpose: To evaluate 5-year postoperative clinical outcomes of autologous matrix-induced chondrogenesis (AMIC) for isolated ICRS grade 3-4 patellar cartilage defects and correlate outcomes with magnetic resonance imaging (MRI). The hypothesis was that AMIC would improve clinical symptoms and induce neocartilage formation, visible on MRI, making it a safe and effective option for repairing focal patellar cartilage defects.
Methods: The cohort comprised 13 focal patellar lesions in 12 patients.
Results of the AMIC® method in patients operated on for an osteochondral lesion of the talar dome (OLTD) at a mean follow-up of 34 months. A retrospective multicenter study.
Orthop Traumatol Surg Res
October 2024
Service de Chirurgie Orthopédique et Traumatologique, Hôpital d'Instruction des Armées Sainte-Anne, 2 Boulevard Sainte-Anne, 83000, Toulon, France.
Background: Symptomatic osteochondral lesions of the talar dome (OLTD) represent a real therapeutic challenge. In the absence of appropriate treatment, these lesions can evolve into tibiotalar osteoarthritis. Stage 3 lesion of the SFA classification and resistant to medical non-operative treatment may require surgical treatment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!