Leprosy is a chronic infectious disease whose disequilibrium in the host's genetic, immunological and clinical mechanisms leads to distinct manifestations defining the type of immunological response. This review focuses its attention on the influence of the Vitamin D Receptor and hepcidin expressions that can suggest the protection or severity of leprosy.
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http://dx.doi.org/10.1016/j.micinf.2017.03.001 | DOI Listing |
J Vis Exp
December 2024
Department of Ophthalmology and Visual Neurosciences, University of Minnesota;
G protein-coupled receptors (GPCRs) are a superfamily of transmembrane proteins that initiate signaling cascades through activation of its G protein upon association with its ligand. In all mammalian vision, rhodopsin is the GPCR responsible for the initiation of the phototransduction cascade. Within photoreceptors, rhodopsin is bound to its chromophore 11-cis-retinal and is activated through the light-sensitive isomerization of 11-cis-retinal to all-trans-retinal, which activates the transducin G protein, resulting in the phototransduction cascade.
View Article and Find Full Text PDFInt J Cell Biol
January 2025
Department of Biotechnology and Plant Breeding, Sari Agricultural Sciences and Natural Resources University (SANRU), Sari, Iran.
Radiation therapy is one of the most effective treatments for approximately 60% of patients with cancer. During radiation exposure, the overproduction of reactive oxygen species (ROS) disrupts the lipid layer of the membrane, leading to subsequent peroxide radical formation. Cimetidine (Cim) and famotidine (Fam) are histamine H2 receptor antagonists (H2 blocker), also known as peptic ulcer drugs, that exert radioprotective effects.
View Article and Find Full Text PDFFood Sci Nutr
January 2025
Department of Nutrition and Food Hygiene, School of Public Health Jilin University Changchun China.
BackgroundAllergic diseases have become one of the major public health problems to be addressed in the world today. As a tissue resident cell, mast cells are crucial in the pathogenesis of allergic diseases. Vitamin A is an important fat-soluble vitamin with immunomodulatory functions.
View Article and Find Full Text PDFJ Inflamm Res
January 2025
Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, 45363, Indonesia.
Background: Patients with transfusion-dependent thalassemia experience iron dysregulation, which affects the immune response. Surface proteins such as FcγRIII (CD16), lipopolysaccharide receptor (CD14), and human leukocyte antigen (HLA-DR) on monocytes are crucial for innate and adaptive responses. Blood monocytes, identified by their CD14 and CD16 expression, show functional diversity during injury or inflammation.
View Article and Find Full Text PDFNutr Res
December 2024
Department of Food and Nutrition, Gangneung-Wonju National University, Gangneung-si, Republic of Korea. Electronic address:
Air pollutants directly and indirectly cause vitamin D deficiency (VDD). In addition, smoking increases oxidative stress and accelerates skin aging, thereby reducing the body's vitamin D concentration. Previous study reported that VDD increases total cholesterol concentration by reducing vitamin D receptor activity.
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