Melanin-concentrating hormone (MCH), the neuropeptide produced mainly in the hypothalamus, plays an operative role in regulating food intake and the sleep/wake cycle. Considering that these physiological functions pursue diurnal variations, we checked whether the total hypothalamic MCH level depends on the time of the day. The aggregated MCH peptide content of the whole MCH neuron population was significantly higher at the end of the sleeping period (lights on), than at the end of the active period (lights off). This result, together with earlier observations, indicates that in contrast to the MCH gene expression, the level of MCH peptide is object of circadian variation in the hypothalamus.
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Article Synopsis
- * Neurons in the lateral hypothalamus, specifically those producing orexin and melanin-concentrating hormone (MCH), play a crucial role in regulating the circadian period of the SCN.
- * Research shows that these peptides can shorten circadian rhythms in the SCN, and their absence leads to prolonged behavioral rhythms in constant darkness, highlighting their importance in circadian modulation.
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