AI Article Synopsis
- Scientists are studying how a substance called phillyrin might help treat obesity by affecting certain pathways in the body.
- They tested phillyrin on mice, comparing it to other treatments and found that it helped reduce their weight and fat levels.
- The results suggest that phillyrin works by changing the way the body uses fat and energy, which could be useful for treating obesity in the future.
Article Abstract
Objective: Previous investigations have shown that the peroxisome proliferator activated receptor beta/delta (PPAR
Method: Fifty mice were randomly divided into 5 groups (n=10): control group (C57BL/6J mice), obese mice group, two groups of obese mice treated with phillyrin (15 or 45mg/kg/day), one group of obese mice treated with PPAR
Results: Treatment with phillyrin (15 or 45mg/kg) significantly decreased body weight, liver weight, fat weight, hepatic total cholesterol, free fatty acid, and triglyceride concentrations, serum levels of TNF-
Conclusions: The present results suggest that phillyrin could regulate the PPAR
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| http://dx.doi.org/10.1016/j.orcp.2017.02.002 | DOI Listing |
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