Introduction: Autosomal recessive spastic ataxia of Charlevoix/Saguenay (ARSACS) is a neuromuscular disorder that induces spasticity in lower limbs. The Wartenberg pendulum test is a classical method of assessing lower limb spasticity based on the dynamics of the pendular leg motion. However, in its original form, this test only provides subjective results and do not allow accurate assessment of spasticity.
Methods: Thirteen ARSACS patients were assessed using a new wireless electrogoniometer to measure spasticity by quantifying oscillation amplitudes and relaxation indices during the Wartenburg pendulum test. The validity of the instrument was evaluated by comparing its measurements to a known precise goniometer whereas discriminant validity was evaluated by comparing healthy participants and ARSACS patients. Reliability was measured using intraclass correlation (ICC) between pendulum test scores obtained at different moments in time.
Results: Data from different tests show that the proposed device is accurate (standard error of measurement of 0.0005°), discriminates healthy and ARSACS patients (most variables have p=0.00) and provides repeatable results (significant ICC usually higher than 0.64 and p<0.05).
Discussion: The proposed tool allows the clinician to analyze pendulum oscillation amplitudes and ratios and thus, provide an index of spasticity for the patients affected by ARSACS. This is important as the original procedure is only evaluated visually and the progression cannot be detected until the condition changes drastically. Thus, the system proposed meets the requirements of being useful, precise and user-friendly in the evaluation of patients in a research as well as a clinical environment.
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http://dx.doi.org/10.1016/j.jns.2017.01.065 | DOI Listing |
Sensors (Basel)
December 2024
Space Environmental Load Engineering Center, Lanzhou Institute of Physics, Lanzhou 730000, China.
Sensors (Basel)
November 2024
School of Science, Technology and Engineering, University of Sunshine Coast, Sippy Downs, QLD 4556, Australia.
Runway surface friction is critically important to safe aircraft operations and mostly depends on the surface texture, which provides grip in the presence of contamination and directly affects the friction coefficient in general. Microtexture assessment is the most challenging part of texture assessment since there is no standardised pavement microtexture control method in runway maintenance and management practice. The purpose of this study was to develop a simple laser profilometer and analysis model and subsequent validation for use in runway friction surveys.
View Article and Find Full Text PDFNutrients
December 2024
Sahlgrenska Osteoporosis Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, 41345 Gothenburg, Sweden.
Background/objectives: Correction of decreased diversity of the gut microbiome, which is characteristic of menopause, by supplementation with a synbiotic may attenuate or prevent dysbiosis processes and preserve bone mass. We describe the rationale and design of the OsteoPreP trial aimed at evaluating the effects of 12 months of supplementation with a synbiotic on bone and metabolic health in postmenopausal Caucasian women.
Methods: This is a randomized, double-blinded, placebo-controlled trial among 160 Caucasian, postmenopausal women with no current diagnosis of osteoporosis or supplementation with pro- or prebiotics, and no medical treatment affecting bone turnover.
J Neural Eng
December 2024
Exercise Physiology, Department of Human Performance, School of Medicine, West Virginia University, Morgantown, WV, United States of America.
Complex biological systems have evolved to control movement dynamics despite noisy and unpredictable inputs and processing delays that necessitate forward predictions. The staple example in vertebrates is the locomotor control emerging from interactions between multiple systems-from passive dynamics of inverted pendulum governing body motion to coupled neural oscillators that integrate predictive forward and sensory feedback signals. These neural dynamic computations are expressed in the rhythmogenic spinal network known as the central pattern generator (CPG).
View Article and Find Full Text PDFSurg Technol Int
November 2024
Stryker, Joint Replacement, Mahwah, New Jeresey.
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