The goal of this study is to investigate the impact of the number of dementia cases in general and specialist practices on the continuity of treatment with antidementia drugs. Period between 2004 and 2013: 1116 general practices, 200 specialist practices, 37 178 dementia cases; observation period: 36 months. Practice groups with 1 - 9, 10 - 20, 21-s49, and ≥ 50 dementia cases. The treatment continuity is higher in practices with an average of 150 dementia cases than in practices with five dementia cases (73.6 % vs. 42.1 %). In addition to the number of cases, treatment continuity is also affected by the specialization, but not by the practice size. Practices with more than 50 patients treated with antidementia drugs exhibit greater treatment continuity. Treatment continuity is increased if specialists are involved in the treatment.
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http://dx.doi.org/10.1055/s-0043-101233 | DOI Listing |
Alzheimer Dis Assoc Disord
January 2025
Department of Psychiatry, University of Michigan, Ann Arbor, MI.
Objectives: Many individuals with dementia with Lewy bodies (DLB) die of disease-related complications, but predicting the end of life can be challenging. We identified a phenotype associated with approaching end of life.
Methods: We present 4 exemplar cases where individuals with DLB experienced refractory psychosis before death.
Front Immunol
January 2025
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Alzheimer's disease (AD) is the most common neurodegenerative disorder, accounting for approximately 70% of dementia cases worldwide. Patients gradually exhibit cognitive decline, such as memory loss, aphasia, and changes in personality and behavior. Research has shown that mitochondrial dysfunction plays a critical role in the onset and progression of AD.
View Article and Find Full Text PDFAlzheimers Dement
January 2025
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Introduction: Iron-mediated cell death (ferroptosis) is a proposed mechanism of Alzheimer's disease (AD) pathology. While iron is essential for basic biological functions, its reactivity generates oxidants which contribute to cell damage and death.
Methods: To further resolve mechanisms of iron-mediated toxicity in AD, we analyzed post mortem human brain and ApoEFAD mice.
J Med Ethics
January 2025
Medicine for Older People, AmsterdamUMC Location VUmc, Amsterdam, The Netherlands.
Euthanasia in dementia based on advance euthanasia directives (AEDs) is possible within the Dutch Euthanasia law. Yet, physicians struggle with the responsibility of interpreting the law's open norms in cases of advanced dementia, which includes the fulfilment of the due care criteria. This Delphi study aims to analyse arguments and seek consensus from medical, ethical and legal perspectives on ethical dilemmas in such cases.
View Article and Find Full Text PDFJ Am Med Dir Assoc
January 2025
Department of Medicine for Older People, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health, Aging and Later Life, Amsterdam, The Netherlands. Electronic address:
Objective: Psychotropic drugs are frequently prescribed for challenging behavior in residents with dementia in nursing homes. Recommendations on psychotropic drug use for challenging behavior are described in the Dutch multidisciplinary guideline "Problem behavior in dementia." This study aimed to gain insight into the adherence to guideline recommendations on drug type and timing of evaluations of different types of psychotropic drugs for challenging behavior in a national sentinel network of Dutch nursing homes.
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