Biofunctionalized Plants as Diverse Biomaterials for Human Cell Culture.

Adv Healthc Mater

Biomedical Engineering, Material Sciences and Engineering, Department of Orthopedics and Rehabilitation, Department of Surgery, University of Wisconsin-Madison, Madison, WI, 53705, USA.

Published: April 2017

The commercial success of tissue engineering products requires efficacy, cost effectiveness, and the possibility of scaleup. Advances in tissue engineering require increased sophistication in the design of biomaterials, often challenging the current manufacturing techniques. Interestingly, several of the properties that are desirable for biomaterial design are embodied in the structure and function of plants. This study demonstrates that decellularized plant tissues can be used as adaptable scaffolds for culture of human cells. With simple biofunctionalization technique, it is possible to enable adhesion of human cells on a diverse set of plant tissues. The elevated hydrophilicity and excellent water transport abilities of plant tissues allow cell expansion over prolonged periods of culture. Moreover, cells are able to conform to the microstructure of the plant frameworks, resulting in cell alignment and pattern registration. In conclusion, the current study shows that it is feasible to use plant tissues as an alternative feedstock of scaffolds for mammalian cells.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490445PMC
http://dx.doi.org/10.1002/adhm.201601225DOI Listing

Publication Analysis

Top Keywords

plant tissues
16
tissue engineering
8
human cells
8
plant
5
biofunctionalized plants
4
plants diverse
4
diverse biomaterials
4
biomaterials human
4
human cell
4
cell culture
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!