A simple, general and practical method is reported for highly enantioselective construction of tertiary alcohols through the direct addition of organomagnesium reagents to ketones. Discovered by rational ligand design based on a mechanistic hypothesis, it has an unprecedented broad scope. It utilizes a new type of chiral tridentate diamine/phenol ligand that is easily removed from the reaction mixture. It is exemplified by application to a formal asymmetric synthesis (>95:5 d.r.) of vitamin E.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201610462 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Application of biomanufacturing in polymer flooding].
Sheng Wu Gong Cheng Xue Bao
January 2025
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
In China, the crude oil supply is highly dependent on overseas countries, and thus strengthening crude oil self-sufficiency has become an important issue of the national energy security. Tertiary oil recovery, especially polymer flooding, has been widely applied in large oil fields in China, which can increase the recovery rate by 15%-20% compared with water flooding. However, the widely used oil flooding polymers show poor thermal stability and salinity tolerance, complicated synthesis ways of monomers, and environmental unfriendliness.
View Article and Find Full Text PDFIdentifying Patient Subgroups in the Heterogeneous Chronic Pain Population Using Cluster Analysis.
J Pain
January 2025
Center for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Chronic pain is an ill-defined disease with complex biopsychosocial aspects, posing treatment challenges. We hypothesized that treatment failure results, at least partly, from limited understanding of diverse patient subgroups. We aimed to identify subgroups using psychological variables, allowing for more tailored interventions.
View Article and Find Full Text PDFClinical features of inflammatory arthritis in daily practice-China's perspective.
Clin Rheumatol
January 2025
Department of Rheumatology and Immunology, Peking University People's Hospital, 11 Xizhimen South Street, Beijing, 100044, China.
Objective: This study aimed to analyze and compare the proportion of patients with different types of inflammatory arthritis and investigate the clinical characteristics, including symptoms and signs, medication choices, and disease activity, in the daily clinical practice of China.
Methods: Patients with inflammatory arthritis were recruited from 16 Grade-A tertiary hospitals between August 2021 and April 2022. The medical profiles, encompassing sociodemographic characteristics, clinical and laboratory date, were collected.
Biosynthesis of the Antifungal Polyhydroxy-Polyketide Acrophialocinol.
Org Lett
January 2025
Institute of Molecular Physiology, Johannes Gutenberg-University, Hanns-Dieter-Huesch-Weg 17, D-55128 Mainz, Germany.
Bioactivity-guided isolation identified the main antifungal compounds produced by as the new polyhydroxy-polyketides acrophialocinol () and acrophialocin (). Their biosynthesis was elucidated by heterologous reconstitution in and involves an α-ketoglutarate-dependent dioxygenase-catalyzed α-hydroxylation, resulting in the formation of a tertiary alcohol that is indispensable for antifungal activity. Furthermore, self-resistance toward the polyhydroxy-polyketides is mediated by a conserved RTA1-like protein encoded in the biosynthetic gene cluster.
View Article and Find Full Text PDFRisk factors of gallbladder cancer in Nepal: A case control study.
PLoS One
January 2025
Department of Public Health, Kathmandu University Dhulikhel Hospital, Dhulikhel, Nepal.
Background: Gallbladder cancer (GBC) is a rare, highly fatal disease with diagnosis in advanced stage and low survival rate. Nepal ranked 4th position with highest rates of GBC for 10 countries in 2020.
Objective: To find the association between socio-demographic, behavioral and environmental factors associated with the development of GBC.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!