Fibro-osseous pseudotumor of the digits is a benign neoplasm that originates in the soft tissue adjacent to the short bones of the hands and feet. We present a case in a 13-year-old girl that was initially misdiagnosed as pyogenic granuloma. Familiarity with this entity and imaging and histologic studies are necessary to avoid incorrect diagnoses and aggressive surgical interventions.
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[Fibro-osseous pseudotumor of the digits: An exemple of USP6-related fibroblastic/myofibroblastic tumor].
Ann Pathol
September 2024
Service d'anatomie et cytologie pathologique, CHU de Grenoble Alpes, 38000 Grenoble, France; Université de Grenoble Alpes, Inserm U1209, CNRS UMR5309, institut pour l'avancée des biosciences, département de pathology, CHU Grenoble Alpes, 38000, Grenoble, France. Electronic address:
Fibro-osseous pseudotumor of the digits is a benign tumour closely related to myositis ossificans. It is a rare lesion seldom reported in the literature. We report the case of a 33-year-old woman with lancinating pain in the first phalanx of the second finger of the right hand, associated with inflammation.
View Article and Find Full Text PDFUnravelling the USP6 gene: an update.
J Clin Pathol
September 2023
Pathology, Ghent University Hospital, Ghent, Belgium
() rearrangements have been identified in aneurysmal bone cyst, nodular fasciitis, myositis ossificans, fibro-osseous pseudotumour of digits and cellular fibroma of tendon sheath. These entities show clinical as well as histological overlap, suggesting they are all clonal neoplastic belonging to the same biological spectrum and referred to as '-associated neoplasms'. They all show a characteristic gene fusion formed by juxtaposition of the coding sequences to the promoter regions of several partner genes, leading to transcriptional upregulation.
View Article and Find Full Text PDF-associated soft tissue tumors with bone metaplasia: Clinicopathologic and genetic analysis and the identification of novel fusion partners.
Front Oncol
January 2023
Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.
Introduction: Among those tumors with consistent USP6 rearrangement, some arise from soft tissue and show bone metaplasia, including myositis ossificans (MO), fibro-osseous pseudotumor of digits (FOPD), soft tissue aneurysmal bone cyst (ST-ABC) and fasciitis ossificans (FO). These lesions are easily confused with malignancies because they show a rapid growth rate and brisk mitoses. Here, we aim to clarify the clinicopathologic and genetic characteristics of this entity and analyze the correlations among the different subtypes in one of the largest cohorts.
View Article and Find Full Text PDFMultimodality imaging features of USP6-associated neoplasms.
Skeletal Radiol
March 2023
Department of Radiology, Mayo Clinic, Charlton Building North, 1st Floor, 200 First Street SW , Rochester, MN, 55905, USA.
Since the discovery of USP6 gene rearrangements in aneurysmal bone cysts nearly 20 years ago, we have come to recognize that there is a family of USP6-driven mesenchymal neoplasms with overlapping clinical, morphologic, and imaging features. This family of neoplasms now includes myositis ossificans, aneurysmal bone cyst, nodular fasciitis, fibroma of tendon sheath, fibro-osseous pseudotumor of digits, and their associated variants. While generally benign and in many cases self-limiting, these lesions may undergo rapid growth, and be confused with malignant bone and soft tissue lesions, both clinically and on imaging.
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- * A case study highlights a 15-year-old boy with a painful protruded SE on his right great toe, diagnosed through physical examination and radiography, and successfully treated with surgery.
- * Post-surgery, the patient showed no signs of recurrence after 6 and 18 months, emphasizing the effectiveness of complete surgical excision and the importance of distinguishing SE from other bony growths.
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