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Self-renewal and phenotypic conversion are the main physiological responses of macrophages to the endogenous estrogen surge. | LitMetric

AI Article Synopsis

  • - The study investigates how estrogen, specifically 17β-estradiol (E), affects macrophages in female mice by examining gene expression in response to the hormone.
  • - Results show that E influences key biological processes in macrophages, such as cell proliferation, immune response, and wound healing, promoting a shift towards an anti-inflammatory phenotype.
  • - The research underscores estrogen's pivotal role in regulating macrophage behavior during homeostasis and inflammatory conditions, suggesting its potential involvement in inflammatory diseases.

Article Abstract

Beyond the physiology of reproduction, estrogen controls the homeostasis of several tissues. Although macrophages play a key role in tissue remodeling, the interplay with estrogen is still ill defined. Using a transcriptomic approach we first obtained a comprehensive list of genes that are differentially expressed in peritoneal macrophages in response to physiological levels of 17β-estradiol (E) injected in intact female mice. Our data also showed the dynamic nature of the macrophage response to E and pointed to specific biological programs induced by the hormone, with cell proliferation, immune response and wound healing being the most prominent functional categories. Indeed, the exogenous administration of E and, more importantly, the endogenous hormonal surge proved to support macrophage proliferation in vivo, as shown by cell cycle gene expression, BrdU incorporation and cell number. Furthermore, E promoted an anti-inflammatory and pro-resolving macrophage phenotype, which converged on the induction of genes related to macrophage alternative activation and on IL-10 expression in vivo. Hormone action was maintained in an experimental model of peritoneal inflammation based on zymosan injection. These findings highlight a direct effect of estrogen on macrophage expansion and phenotypic adaptation in homeostatic conditions and suggest a role for this interplay in inflammatory pathologies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357836PMC
http://dx.doi.org/10.1038/srep44270DOI Listing

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