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Identification and validation of a prognostic signature of drug resistance and mitochondrial energy metabolism-related differentially expressed genes for breast cancer.
J Transl Med
January 2025
Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People's Republic of China.
Background: Drug resistance constitutes one of the principal causes of poor prognosis in breast cancer patients. Although cancer cells can maintain viability independently of mitochondrial energy metabolism, they remain reliant on mitochondrial functions for the synthesis of new DNA strands. This dependency underscores a potential link between mitochondrial energy metabolism and drug resistance.
View Article and Find Full Text PDFImproved constructs for bait RNA display in a bacterial three-hybrid assay.
Sci Rep
January 2025
Program in Biochemistry, Mount Holyoke College, South Hadley, MA, 01075, USA.
We have previously developed a transcription-based bacterial three-hybrid (B3H) assay as a genetic approach to probe RNA-protein interactions inside of E. coli cells. This system offers a straightforward path to identify and assess the consequences of mutations in RBPs with molecular phenotypes of interest.
View Article and Find Full Text PDFHigh-Yield Cellulose Nanocrystals from Bleached Eucalyptus Fibers via Maleic Acid Hydrothermal Treatment and High-Pressure Homogenization.
Biomacromolecules
January 2025
LMSE - Faculty of Science, University of Sfax, BP 802, Sfax 3018, Tunisia.
This study reports the preparation of cellulose nanocrystals (CNCs) from commercial bleached eucalyptus Kraft pulp (BEKP) using a hydrothermal treatment in the presence of maleic acid (MA), followed by high-pressure homogenization. Compared with conventional hydrolysis methods, this approach offers significant advantages, including lower acid concentration, higher yield, and milder processing conditions. CNCs were produced with a high yield (70-85 wt %) by high-pressure homogenization of hydrothermally treated BEKP fibers with 10-20 wt % maleic acid at 150 °C, giving rise to a stable translucent gel of CNCs with a rod-like morphology (200-400 nm length and 10-40 nm width).
View Article and Find Full Text PDFPredictors and Implications of Myocardial Injury in Intracerebral Hemorrhage.
Clin Neuroradiol
January 2025
Department of Neurology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
Purpose: Myocardial injury, indicated by an elevation of high-sensitive cardiac Troponin (hs-cTnT), is a frequent stroke-related complication. Most studies investigated patients with ischemic stroke, but only little is known about its occurrence in patients with intracerebral hemorrhage (ICH). This study aimed to assess the frequency, predictors, and implications of myocardial injury in ICH patients.
View Article and Find Full Text PDF[New approaches for pathology teaching in undergraduate medical studies, the University Paris-Saclay experience].
Ann Pathol
January 2025
Service d'anatomie et cytologie pathologiques, hôpital Bicêtre, AP-HP, université Paris-Saclay, Le Kremlin-Bicêtre, France; Faculté de médecine, université Paris-Saclay, Le Kremlin-Bicêtre, France.
Introduction: Teaching pathology is an essential and early part of the medical curriculum. It is classically theoretical, often accompanied by tutorials. Access to pathology internships for students is not always possible.
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