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Long-Term Observations on the European Photopatch Test Baseline Series (EPTBS) in Real Clinical Practice: 11 Years of Results in a Spanish Cohort and Suggestions for an EPTBS Update.
Contact Dermatitis
December 2024
Department of Dermatology, Hospital Clínic de Barcelona, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.
Background: The European Photopatch Testing Baseline Series (EPTBS) was published in 2013. However, limited data exist regarding the real-world clinical application of the EPTBS.
Objectives: This study aims to describe the photopatch test experience with the EPTBS over 11 years at a tertiary hospital in Spain.
Panthenol Allergic Contact Dermatitis: Sources of Exposure, Reported Cases, and a Call for More Frequent Testing.
Dermatitis
December 2024
From the Department of Dermatology, Park Nicollet Contact Dermatitis Clinic, Minneapolis, MN, USA.
Panthenol, a vitamin B5 derivative, is a key precursor in the synthesis of fatty acids that maintain epithelial function. Its ability to aid in moisturization, skin barrier restoration, and wound healing has led to its frequent incorporation into personal care products and pharmaceuticals-many of which are marketed to be hypoallergenic. While contact allergy to panthenol is rather uncommon, rates of positive reactions are on the rise, increasing from 0.
View Article and Find Full Text PDFAllergens in ophthalmic medicaments in New Zealand.
Australas J Dermatol
December 2024
Department of Dermatology, Auckland City Hospital, Te Whatu Ora Health, New Zealand.
Background/objectives: Eyelid allergic contact dermatitis (ACD) attributed to ophthalmic medications is often underreported, which can result in poor outcomes. Patch testing for eyelid ACD requires up-to-date knowledge of potential allergens. The aim of this study was to investigate allergens in ophthalmic medicaments in New Zealand.
View Article and Find Full Text PDFDevelopment of machine learning models for the prediction of the skin sensitization potential of cosmetic compounds.
PeerJ
December 2024
Pigeon Manufacturing (Shanghai) Co., Ltd., Shanghai, China.
Background: To enhance the accuracy of allergen detection in cosmetic compounds, we developed a co-culture system that combines HaCaT keratinocytes (transfected with a luciferase plasmid driven by the AKR1C2 promoter) and THP-1 cells for machine learning applications.
Methods: Following chemical exposure, cell cytotoxicity was assessed using CCK-8 to determine appropriate stimulation concentrations. RNA-Seq was subsequently employed to analyze THP-1 cells, followed by differential expression gene (DEG) analysis and weighted gene co-expression net-work analysis (WGCNA).
Cinnamic Acid Derivatives as Potential Multifunctional Agents in Cosmetic Formulations Used for Supporting the Treatment of Selected Dermatoses.
Molecules
December 2024
Department of Bioorganic Chemistry, Chair of Organic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, Poland.
Cinnamic acid and its natural derivatives were primarily used in cosmetics as fragrance materials as well as skin and hair conditioners. Nowadays, not only natural but also synthetic cinnamic acid derivatives are used as active ingredients of cosmetic formulations. They still serve as fragrance ingredients but also as active ingredients supporting the treatment of selected dermatoses such as acne vulgaris, atopic dermatitis, and hyperpigmentation.
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