Facile synthesis of multifunctional silver nanoparticles using mangrove plant L. for its antibacterial, antioxidant and cytotoxic effects.

J Parasit Dis

Division for Nanobiotechnology, Department of Botany and Biotechnology, J.J. College of Arts and Science, Pudukkottai, Tamil Nadu India.

Published: March 2017

The current study describes a simple, rapid and eco-friendly method for the synthesis of silver nanoparticles (AgNPs) using () leaf extract as stabilizer, bioreductant and capping agent. Synthesized AgNPs were characterized by UV-Visible spectroscopy (UV-Vis), X-ray diffraction (XRD), fourier transform infrared (FT-IR) spectroscopy, field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDX). Generation of AgNPs was initially confirmed with the color change from yellow to dark brown which produces intense absorbance spectra at 440 nm in UV-Vis spectroscopy without any shifting of peaks. Further, XRD pattern confirms that the synthesized AgNPs was face centered cubic (fcc) crystalline in structure with an average size of 20 nm. On the other hand, FTIR spectrum reveals that the active metabolites like water soluble phenolic compounds, flavonoids, methylene groups, amides and carboxylate groups. These active biocompounds plays a vital role in the reduction of Ag into their nanoscale values, it also acts as a stabilizing and surface functionalization agent. FESEM micrographs of synthesized AgNPs shows spherical and hexagonal shaped well dispersed particles in the dimension ranging between 23 and 42 nm. EDAX confirms the presence of silver (Ag) as the major constituent element without any impurities; also substantiate the stability of generated AgNPs. The biomedical insights of nanoparticles (NPs) were assessed through radical scavenging and antibacterial properties. Additionally, synthesized AgNPs was also exhibits an excellent cytotoxic effect against human breast carcinoma cell lines (MCF-7). This study proves that synthesized AgNPs can be developed as a potential nano-drug formulation to combat pathogenic disease and also for the expansion of breast cancer therapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339196PMC
http://dx.doi.org/10.1007/s12639-016-0773-6DOI Listing

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