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Efficacy and safety of gut microbiome-targeted treatment in patients with depression: a systematic review and meta-analysis.
BMC Psychiatry
January 2025
Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China.
Background: The study aimed to comprehensively analyze and establish a framework for evaluating the efficacy of microbiome-targeted treatment (MTT) for depression.
Methods: We searched PubMed, Embase, Cochrane Library, Web of Science, and the Chinese National Knowledge Infrastructure database for randomized controlled trials (RCTs) on MTT in treating depression until October 19, 2023. A meta-analysis was conducted to evaluate the efficacy and safety of MTT.
Digging deeper into necrotizing enterocolitis: bridging clinical, microbial, and molecular perspectives.
Gut Microbes
December 2025
Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University, Chengdu, China.
Necrotizing Enterocolitis (NEC) is a severe, life-threatening inflammatory condition of the gastrointestinal tract, especially affecting preterm infants. This review consolidates evidence from various biomedical disciplines to elucidate the complex pathogenesis of NEC, integrating insights from clinical, microbial, and molecular perspectives. It emphasizes the modulation of NEC-associated inflammatory pathways by probiotics and novel biologics, highlighting their therapeutic potential.
View Article and Find Full Text PDFLactation, mastitis, and probiotics.
Arch Argent Pediatr
January 2025
Instituto de Lactología Industrial (INLAIN, CONICET-UNL), Faculty of Chemical Engineering, Universidad Nacional del Litoral, Santa Fe, Argentina.
Exclusive breastfeeding during the first six months of life, and prolonged with complementary feeding until 2 years of age or more, is the best nutritional approach in the first stage of life. Mastitis is a pathology that can jeopardize the continuity of breastfeeding. Different methods have been proposed for the prevention and treatment of mastitis, including probiotics.
View Article and Find Full Text PDFDietary interventions to reduce heavy metal exposure in antepartum and postpartum women: a systematic review.
Womens Health Nurs
December 2024
College of Nursing Science, Kyung Hee University, Seoul, Korea.
Purpose: Heavy metals, which are persistent in the environment and toxic, can accumulate in the body and cause organ damage, which may further negatively affect perinatal women and their fetuses. Therefore, this systematic review was conducted to evaluate the effectiveness of dietary interventions to reduce heavy metal exposure in antepartum and postpartum women.
Methods: We searched five databases (PubMed, Embase, Scopus, Web of Science, and Cochrane Library) for randomized controlled trials that provided dietary interventions for antepartum and postpartum women.
Maternal probiotic exposure enhances CD8 T cell protective neonatal immunity and modulates offspring metabolome to control influenza virus infection.
Gut Microbes
December 2025
Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.
Maternal gut microbiota composition contributes to the status of the neonatal immune system and could influence the early life higher susceptibility to viral respiratory infections. Using a novel protocol of murine maternal probiotic supplementation, we report that perinatal exposure to () or () increases the influenza A/PR8 virus (IAV) clearance in neonates. Following either supplementation, type 1 conventional dendritic cells (cDC1) were amplified in the lymph nodes leading to an enhanced IAV antigen-experienced IFN-γ producing effector CD8 T cells in neonates and IAV-specific resident memory CD8 T cells in adulthood.
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