Purpose: To present the results of research aimed at developing a new method of minimally invasive removal of an intraocular foreign body (IOFB) from the eye cavity.
Methods: The main idea was to fix the IOFB onto the edge of a laser probe, which is transsclerally injected into the eye. After that, the IOFB is fixed at the end of the laser probe and removed transpupillary from the eye through an incision in the cornea. In order to fix the IOFB on the laser probe edge, this edge should be brought closely to the IOFB surface. The material of the IOFB should be locally fused using the laser emission. During this process, the probe edge should be submerged into the liquid melt. After laser emission is turned off, the material around the probe is hardened and the IOFB is hardly fixed on the laser probe edge.
Results And Conclusions: The main laser emission parameters and their influence on the eye tissue were investigated within a thermodynamic model. It is shown that for IOFB made from polyethylene terephthalate the optimal laser power is close to 2 W, the rate of rise of light energy is more than 10 ms, and the wavelength is approximately 0.905 μm. With these parameters (taking into account multiple scattering effects), the light impact on the retina will not exceed 100 mW/cm2, which is not dangerous for eye tissue. Efficiency is supported by clinical testing. The method was used for intraocular extraction of an Airsoft ball bearing (6 mm sphere of polyethylene terephthalate).The overall extraction time was approximately 4 minutes.
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http://dx.doi.org/10.5301/ejo.5000945 | DOI Listing |
World J Urol
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Department of Urology, Ruby Hall Clinic, Pune, India.
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United European Gastroenterol J
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Department of Gastroenterology, CHU Liège, Liège, Belgium.
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January 2025
Science and Technology on Vacuum and Physics Laboratory, Lanzhou Institute of Physics, Lanzhou, 730000, China.
The Laser Interferometer Space Antenna (LISA) mission is designed to detect space gravitational wave sources in the millihertz band. A critical factor in the success of this mission is the residual acceleration noise metric of the internal test mass (TM) within the ultra-precise inertial sensors. Existing studies indicate that the coupling effects of residual gas and temperature gradient fluctuations significantly influence this metric, primarily manifesting as the radiometer effect and the outgassing effect.
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Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China.
Hepatocellular carcinoma (HCC) is typically diagnosed at intermediate to advanced stage, making surgical treatment unfeasible. Conversion therapy aims to reduce tumor stage, improve hepatic resection feasibility, and lower recurrence rates. Since traditional therapies are often accompanied by uncertainty of efficacy, there is an urgent need to explore new treatment strategies.
View Article and Find Full Text PDFAnal Chem
January 2025
School of Environmental & Chemical Engineering, Jiangsu University of Science and Technology, Changhui Rd. 666, Zhenjiang, Jiangsu 212003, China.
Early diagnosis of tumors allows effective treatment of primary cancers through localized therapeutic interventions. However, developing diagnostic tools for sensitive, simple, and early tumor (especially less than 2 mm in diameter) detection remains a challenge. Herein, we presented a biomarker-activatable nanoprobe that enabled a near-infrared (NIR) photothermally amplified signal for fluorescence imaging and urinalysis of tumor.
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