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Privileged natural product compound classes for anti-inflammatory drug development.
Nat Prod Rep
March 2025
Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore, 18 Science Drive 4, 117543, Singapore.
Covering: up to early 2025Privileged compound classes of anti-inflammatory natural products are those where there are many reported members that possess anti-inflammatory properties. The identification of these classes is of particular relevance to drug discovery, as they could serve as valuable starting points in developing effective and safe anti-inflammatory agents. The privileged compound classes of natural products include the polyphenols, coumarins, labdane diterpenoids, sesquiterpene lactones, isoquinoline and indole alkaloids, each offering a variety of molecular scaffolds and functional groups that enable diverse interactions with biological targets.
View Article and Find Full Text PDFEffects of immersive virtual reality-based action observation training integrated with focal muscle vibration on upper extremity in a patient with chronic disability following stroke: a single-subject study.
Physiother Theory Pract
March 2025
Physiotherapy Unit, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
Background: The association of different sensory inputs enhances brain plasticity in patients after stroke, but no studies have associated Action Observation Training (AOT) delivered in immersive virtual reality (VR) with Focal Vibration (FV) to elicit a kinesthetic illusion coherent with the observed task to improve motor function.
Objective: The study aimed to evaluate the feasibility of AOT delivered in immersive VR integrated with FV of upper limb muscles on manual dexterity in patients with chronic stroke.
Methods: A single-subject study was conducted (A-B design).
Neonatal lupus erythematosus: an acquired autoimmune disease to be taken seriously.
Ann Med
December 2025
Department of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Aim: This review aims to summarize the epidemiology, pathogenesis, clinical features, management, prognosis and regression of Neonatal lupus erythematosus (NLE) with a view to providing directions for standardized diagnosis, treatment and further research.
Methods: We conducted a comprehensive literature review of NLE. NLE-related peer-reviewed papers were searched through PubMed/Medline were searched up to November 2024.
Acute kidney injury after lung transplantation, incidence, risk factors, and effects: A Swedish nationwide study.
Acta Anaesthesiol Scand
April 2025
Department of Anesthesiology and Intensive Care Medicine, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg and Section for Cardiothoracic Anesthesia and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden.
Background: Acute kidney injury (AKI) is a serious complication after lung transplantation, but the reported incidence varies in the literature. No data on AKI have been published from the Swedish lung transplantation program.
Methods: The aim of our study was to investigate the incidence, perioperative risk factors, and effects of early postoperative acute kidney injury (Kidney Disease Improving Global Outcomes [KDIGO] criteria) after lung transplantation.
Arid4a Suppresses Breast Tumor Metastasis by Enhancing MTSS1 Expression via mRNA Stability.
Cancer Med
March 2025
Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Background: Tumor metastasis is one of the main causes of death in cancer patients; however, the mechanism controlling metastasis is unclear. The posttranscriptional regulation of metastasis-related genes mediated by AT-rich interactive domain-containing protein 4A (Arid4a), an RNA-binding protein (RBP), has not been elucidated.
Methods: Bioinformatic analysis, qRT-PCR, immunohistochemistry, and immunoblotting were employed to determine the expression of Arid4a in breast tumor tissues and its association with the survival of cancer patients.
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