For plant species, the most immediate function of dispersal is the placement of propagules in safe sites where they can grow and survive. The efficacy of any mode of dispersal is measured by the number of propagules so placed, and depends on the distribution of distances traveled by propagules and by the density of safe sites. A graphical model is developed to describe the relationship between these two factors, and to provide a method for comparing the efficacy of dispersal in different species. When safe sites are rare, distributions of distances with long tails are most efficacious; when safe sites are more abundant, distributions with broader peaks are more suitable. This analysis is shown to apply in a qualitative fashion to a group of species inhabiting the eastern forests of North America.
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http://dx.doi.org/10.1007/BF00379712 | DOI Listing |
Trans R Soc Trop Med Hyg
January 2025
Conse jo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Básica y Aplicada del Nordeste Argentino (IQUIBA-NEA), CP3400 Corrientes, Argentina.
Background: The WHO states that antivenom is the only safe and effective treatment to neutralize snake venom. Snakebite antivenom typically involves horse hyperimmunization with crude venom and Freund's adjuvant.
Methods: In the current work, we analyzed the ascorbyl palmitate liquid crystal structure with snake protein or PLA2, the carrier charge capacity, and we evaluated the immune response induced by the enzyme P9a(Cdt-PLA2) formulated in a nanostructure using CpG-ODN, determining the titer of IgG antibodies.
Mol Biol Res Commun
January 2025
Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.
The recent pernicious COVID-19 pandemic is caused by SARS-CoV-2. While most therapeutic strategies have focused on the viral spike protein, Open Reading Frame 8 (ORF8) plays a critical role in causing the severity of the disease. Nonetheless, there still needs to be more information on the ORF8 binding epitopes and their appropriate safe inhibitors.
View Article and Find Full Text PDFJ Cancer
January 2025
Department of Urology, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
Intravesical instillation of chemotherapy has been performed to reduce the risk of intravesical recurrence of bladder cancer. However, its antitumor effect is not necessarily sufficient, which may be partially due to inadequate delivery of intravesically administered chemotherapeutic agents to bladder tumors. Ultrasound irradiation to target tissues in the presence of microbubbles is a technique to transiently enhance cell membrane permeability and achieve efficient drug delivery to the desired sites without damage to non-target areas; this technique has been used in chemotherapy, immunotherapy, gene therapy, and radiotherapy for the treatment of various cancers.
View Article and Find Full Text PDFMed Devices (Auckl)
December 2024
Jehangir Clinical Development Centre, Pune, Maharashtra, India.
Purpose: The study aimed to assess the safety, tolerability, and acceptability of the IntegriMedical® Needle Free Injection System (IM-NFIS) compared to conventional hypodermic needle injections (CHN) in healthy adult subjects across multiple injection sites.
Patients And Methods: Thirty healthy male subjects aged 18-45 years were enrolled in this open-label study. Each subject received both NF and CHN injections at five different sites (forearm, abdomen, thigh, buttocks, and arm).
J Hazard Mater
December 2024
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, Riyadh 11451, Saudi Arabia.
Human activities have far-reaching impact on natural ecosystems, causing increasing disturbances and disruptions to the delicate balance of the environment. Poor land use planning, urbanization, infrastructure development, and unplanned tourism exacerbate contamination and degradation in tourist destinations, yet the pollution of potentially toxic elements (PTEs) in these environments remains inadequately explored. To address this issue, we investigated the concentrations of acid-digested PTEs in road dust in Abbottabad city (Pakistan) with heavy traffic.
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