AI Article Synopsis
- The study aimed to investigate the link between urolithiasis and chronic kidney disease (CKD) in cats using a retrospective case-control approach.
- Out of 126 cats surveyed, those with urolithiasis showed a significantly higher prevalence of CKD compared to those without, while no other factors like age, weight, or breed influenced the results.
- The findings suggest that cats with urolithiasis should be checked for CKD, highlighting the need for more research to understand the relationship between the two conditions.
Article Abstract
OBJECTIVE To determine whether urolithiasis is associated with chronic kidney disease (CKD) in cats. DESIGN Retrospective case-control study. ANIMALS 126 cats (59 and 67 with and without urolithiasis, respectively). PROCEDURES Medical records from June 2006 to July 2013 were searched to identify cats that underwent abdominal or focal urinary tract ultrasonography and for which serum creatinine concentration and urine specific gravity data were obtained ≤ 14 days before or after the examination. In cats with (urolithiasis group) and without (control group) urolithiasis, the presence of CKD was determined according to International Renal Interest Society guidelines. Information recorded included signalment, body weight, serum creatinine concentration, and urine specific gravity; when present, the location and number of uroliths were noted. Differences between groups and associations between group and categorical variables were analyzed statistically. RESULTS Age, weight, sex, and breed did not differ between groups. The prevalence of CKD was significantly higher in cats with urolithiasis than in the control group. Among cats with urolithiasis, there was a negative association between CKD and presence of cystoliths. There was no association between urolithiasis and the stage of CKD or between presence of CKD and location of nephroliths in the kidney. CONCLUSIONS AND CLINICAL RELEVANCE Results confirmed a positive association between urolithiasis and CKD in the feline population studied and suggested that cats with urolithiasis should be evaluated for CKD. Further research is warranted to assess the nature of the relationship between CKD and urolithiasis in cats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2460/javma.250.7.770 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Feline urethral obstruction alters the urinary microbiota and comparison to oral, preputial, and rectal microbiotas.
Am J Vet Res
January 2025
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO.
Objective: To document differences in the microbiota of healthy cats versus cats with urethral obstruction (UO); compare the urinary microbiota with the oral, preputial, and rectal microbiota; and demonstrate that 16S rRNA gene sequencing will reveal rich and diverse urinary microbiota.
Methods: 15 client-owned cats with UO and 15 age-matched healthy cats were included from July 2020 through April 2021. Exclusion criteria were evidence of urinary tract infection, urolithiasis, antimicrobial administration, urinary catheterization in the past 30 days, or a comorbidity.
Comparison of cat stone matrix and cat urine proteomes to human calcium oxalate stone matrix and urine proteomes.
Urolithiasis
September 2024
Department of Urology, Department of Veterans Affairs Medical Center, Clement J Zablocki VA Medical Center, 5000 W National Avenue (111K), Milwaukee, WI, 53295, USA.
Article Synopsis
- A study compared the proteomes of calcium oxalate monohydrate kidney stones in cats and humans, revealing substantial similarities but limited analysis due to a lack of cat urine proteomic data.
- Urine proteome data from 7 healthy cats was gathered and compared to human urine and cat calcium oxalate stone matrices to identify shared enrichment patterns.
- The findings indicated that cat urine proteins showed distribution similarities to human urine, while differences in cat struvite stone matrices suggest distinct mechanisms of stone formation involving both protein interactions and crystal aggregation.
Survey of veterinarians in the USA to evaluate trends in the treatment approach for non-obstructive feline idiopathic cystitis.
J Feline Med Surg
August 2024
Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA.
Objectives: The goal of this study was to gather information on treatment approaches and trends for the treatment of non-obstructive feline idiopathic cystitis (FIC).
Methods: An internet-based survey of veterinarians was conducted focusing on outpatient treatment approaches for cats that are stable, not obstructed and that exhibit lower urinary signs suspected to be due to FIC, where other causes (eg, urolithiasis, urinary tract infection, other) have been ruled out.
Results: A total of 606 veterinarians submitted complete surveys for inclusion.
Gut and Urinary Microbiota in Cats with Kidney Stones.
Microorganisms
May 2024
Nutrition, PathoPhysiology and Pharmacology (NP3) Unit, Oniris VetAgro Bio, Nantes-Atlantic College of Veterinary Medicine, Food Science and Engineering, La Chantrerie, CEDEX 03, 44 307 Nantes, France.
Article Synopsis
- Upper urinary tract urolithiasis in cats is primarily caused by calcium oxalate stones, with disturbances in gut and urinary microbiota potentially playing a role in their formation.
- The study examined nine cats with kidney stones and nine healthy cats, finding that those with stones had a less diverse gut microbiota and that antibiotic treatment reduced diversity in both groups.
- The research suggests that specific intestinal bacteria may help degrade oxalate, and their absence could lead to stone formation, indicating that modifying microbiota could be a way to prevent kidney stones in cats.
First analytical confirmation of drug-induced crystal nephropathy in felines caused by GS-441524, the active metabolite of Remdesivir.
J Pharm Biomed Anal
September 2024
Dept. of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, 70 President St, Charleston, SC 29425, USA. Electronic address:
GS-441524 is an adenosine nucleoside antiviral demonstrating significant efficacy in the treatment of feline infectious peritonitis (FIP), an otherwise fatal illness, resulting from infection with feline coronavirus. However, following the emergence of COVID-19, veterinary development was halted, and Gilead pursued clinical development of a GS-441524 pro-drug, resulting in the approval of Remdesivir under an FDA emergency use authorization. Despite lack of regulatory approval, GS-441524 is available without a prescription through various unlicensed online distributors and is commonly purchased by pet owners for the treatment of FIP.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!