Facile synthesis of chlorin bioconjugates by a series of click reactions.

Chem Commun (Camb)

Department of Chemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA. and Chemistry Program, Graduate Center of the City University of New York, 365 5th Avenue, New York, New York 10016, USA and Rockefeller University, 1230 York Avenue, New York, New York 10065, USA.

Published: March 2017

A multifunctional chlorin platform appended with four short polyethylene glycols and a carboxylate-linker allows rapid conjugation to biotargeting motifs such as proteins and oligonucleotides. The stability and photophysical properties of the chlorin enable development of diagnostics, imaging, molecular tracking, and theranostics.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463999PMC
http://dx.doi.org/10.1039/c7cc01265aDOI Listing

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