Preterm birth is the leading cause of childhood mortality and can lead to health risks in survivors. The mechanical functions of the uterus, fetal membranes, and cervix have dynamic roles to protect the fetus during gestation. To understand their mechanical function and relation to preterm birth, we built a three-dimensional parameterized finite element model of pregnancy. This model is generated by an automated procedure that is informed by maternal ultrasound measurements. A baseline model at 25 weeks of gestation was characterized, and to visualize the impact of cervical structural parameters on tissue stretch, we evaluated the model sensitivity to (1) anterior uterocervical angle, (2) cervical length, (3) posterior cervical offset, and (4) cervical stiffness. We found that cervical tissue stretching is minimal when the cervical canal is aligned with the longitudinal uterine axis, and a softer cervix is more sensitive to changes in the geometric variables tested.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104753 | PMC |
| http://dx.doi.org/10.1115/1.4036259 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
On-chip cryogenic low-pass filters based on finite ground-plane coplanar waveguides for quantum measurements.
Rev Sci Instrum
January 2025
Indian Institute of Science Education and Research, Thiruvananthapuram, Kerala 695551, India.
Quantum technology exploits fragile quantum electronic phenomena whose energy scales demand ultra-low electron temperature operation. The lack of electron-phonon coupling at cryogenic temperatures makes cooling the electrons down to a few tens of millikelvin a non-trivial task, requiring extensive efforts on thermalization and filtering high-frequency noise. Existing techniques employ bulky and heavy cryogenic metal-powder filters, which prove ineffective at sub-GHz frequency regimes and unsuitable for high-density quantum circuits such as spin qubits.
View Article and Find Full Text PDFBuoyancy-driven flow for surface reaction on vertical walls in multilayered open cavities.
Heliyon
January 2025
Department of Mathematics, University of Dhaka, Dhaka 1000, Bangladesh.
This study analyzes the influences of surface reactions on the natural convective flow, temperature, and oxygen concentration distributions in vertically placed multilayered cavities. A mathematical model for this problem is formulated with proper boundary conditions. At first, the governing equations are made dimensionless using the variable transformations.
View Article and Find Full Text PDFBending behavior and influence parameter optimization of connection joints of disc-buckle type formwork support.
Sci Rep
January 2025
China Construction Fifth Engineering Division Corp., Ltd., Changsha, 410004, China.
In order to systematically study the bending behavior of the connection joints of the disc-buckle type formwork support, the accurate numerical model of the disc-buckle type connection joints was obtained through the experimental on the bending behavior of the connection joints of the disc-buckle type, and the bending moment-rotation curve of the joints was verified. The analysis of the failure mode and stress distribution of the joints reveals the importance of the bending behavior of each component. By establishing an accurate numerical model of the joint, the accuracy of the bending experiment of the joint was verified, and the parametric analysis of the influence factors such as the depth of the wedge insertion the disk-plate, the initial position of the wedge insertion the disk-plate, the thickness of the wedge, material constitutive of the wedge and the thickness of the disk-plate was carried out to grasp the influence of the relevant parameters on the bending behavior of the joint.
View Article and Find Full Text PDFRotating radial injection pattern for highly sensitive electrical impedance tomography of human lung anomalies.
Physiol Meas
January 2025
Chair of Measurements and Sensor Technology, Technische Universitat Chemnitz, Reichenhainerstrasse 70, Chemnitz, 09111, GERMANY.
Objective: Electrical Impedance Tomography (EIT) is a non-invasive technique used for lung imaging. A significant challenge in EIT is reconstructing images of deeper thoracic regions due to the low sensitivity of boundary voltages to internal conductivity variations. The current injection pattern is decisive as it influences the current path, boundary voltages, and their sensitivity to tissue changes.
View Article and Find Full Text PDFTowards constructing a generalized structural 3D breathing human lung model based on experimental volumes, pressures, and strains.
PLoS Comput Biol
January 2025
Department of Mechanical Engineering, University of California Riverside, Riverside, California, United States of America.
Respiratory diseases represent a significant healthcare burden, as evidenced by the devastating impact of COVID-19. Biophysical models offer the possibility to anticipate system behavior and provide insights into physiological functions, advancements which are comparatively and notably nascent when it comes to pulmonary mechanics research. In this context, an Inverse Finite Element Analysis (IFEA) pipeline is developed to construct the first continuously ventilated three-dimensional structurally representative pulmonary model informed by both organ- and tissue-level breathing experiments from a cadaveric human lung.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!