AI Article Synopsis
Article Abstract
Background: Maintaining cerebral oxygen delivery and metabolism during cardiac arrest (CA) through resuscitation is essential to improve the survival rate while avoiding brain injury. The effect of CA and cardiopulmonary resuscitation (CPR) on cerebral and muscle oxygen delivery and metabolism is not clearly quantified.Methods and Results:A novel hyperspectral near-infrared spectroscopy (hNIRS) technique was developed and evaluated to measure cerebral oxygen delivery and aerobic metabolism during ventricular fibrillation (VF) CA and CPR in 14 pigs. The hNIRS parameters were measured simultaneously on the dura and skull to investigate the validity of non-invasive hNIRS measurements. In addition, we compared the hNIRS data collected simultaneously on the brain and muscle. Following VF induction, oxygenated hemoglobin (HbO) declined with a 9.9 s delay and then cytochrome-c-oxidase (Cyt-ox) decreased on average 4.4 s later (P<0.05). CPR improved cerebral metabolism, which was reflected by an average 0.4 μmol/L increase in Cyt-ox, but had no significant effect on HbO, deoxygenated hemoglobin (HHb) and tissue oxygen saturation (tSO). Cyt-ox had greater correlation with HHb than HbO. Muscle metabolism during VF and CPR was significantly different from that of the brain. The total hemoglobin concentration (in the brain only) increased after ~200 s of untreated CA, which is most likely driven by cerebral autoregulation through vasodilation.
Conclusions: Overall, hNIRS showed consistent measurements of hemodynamics and metabolism during CA and CPR.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1253/circj.CJ-16-1225 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Update on Strategies to Reduce Early Brain Injury after Subarachnoid Hemorrhage.
Curr Neurol Neurosci Rep
December 2024
The NABI institute, Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Purpose Of Review: Early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (SAH) is the most influential clinical determinant of outcomes. Despite significant advances in understanding of the pathophysiology of EBI, currently no treatments to target EBI have been developed. This review summarizes recent advances in EBI research over the past five years with a focus on potential therapeutic targets.
View Article and Find Full Text PDFSystematic review: Mechanisms of photoactive nanocarriers for imaging and therapy including controlled drug delivery.
Eur J Nucl Med Mol Imaging
December 2024
Department of Biomedical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
Background: The design of smart, photoactivated nanomaterials for targeted drug delivery systems (DDS) has garnered significant research interest due in part to the ability of light to precisely control drug release in specific cells or tissues with high spatial and temporal resolution. The development of effective light-triggered DDS involves mechanisms including photocleavage, photoisomerization, photopolymerization, photosensitization, photothermal phenomena, and photorearrangement, which permit response to ultraviolet (UV), visible (Vis), and/or Near Infrared (NIR) light. This review explores recent advancements in light-responsive small molecules, polymers, and nanocarriers, detailing their underlying mechanisms and utility for drug delivery and/or imaging.
View Article and Find Full Text PDFMucoadhesive Enhancement of Gelatine by Tannic Acid Crosslinking for Buccal Application.
Biopolymers
January 2025
Faculty of Pharmacy, Universiti Teknologi MARA, Selangor Branch, Puncak Alam Campus, Puncak Alam, Selangor, Malaysia.
This study aims to evaluate the impact of formulation parameters on tannic acid-crosslinked gelatine (GelTA) films, intended as a mucoadhesive matrix for extended buccal drug delivery. GelTA films were prepared using the solvent evaporation technique and screened based on their mucoadhesive and dissolution characteristics. The formulation variables included the source of gelatine (bovine and fish), tannic acid concentration, pH of the film-forming solutions, and the type and concentration of plasticisers.
View Article and Find Full Text PDFMolecular Dynamics Study of Chitosan Adsorption at a Silica Surface.
J Phys Chem C Nanomater Interfaces
December 2024
Department of Chemical and Process Engineering, University of Strathclyde, 75 Montrose Street, Glasgow G1 1XJ, U.K.
Chitosan is a nontoxic biopolymer with many potential biomedical and material applications due to its biodegradability, biocompatibility, and antimicrobial properties. Here, fully atomistic molecular dynamics simulations and enhanced sampling methods have been used to study the adsorption mechanism of chitosan oligomers on a silica surface from an aqueous solution. The free energy of adsorption of chitosan on a silica surface was calculated to be 0.
View Article and Find Full Text PDF"All-in-one" nano-system for smart delivery and imaging-guided combination therapy of triple-negative breast cancer.
J Colloid Interface Sci
December 2024
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China. Electronic address:
Triple-negative breast cancer (TNBC) with highly malignant and aggressive, still faces challenges in treatment due to the single treatment and side effects. It is urgent to develop an advanced theranostic platform against TNBC. Herein, an "all-in-one" nano-system Au/Cu nanodots/doxorubicin@nanospheres (Au/CuNDs/DOX@NS) with dual-responsive properties was designed for dual-mode imaging-guided combination treatment of TNBC.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!