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Predictors and moderators of treatment outcome in patients receiving multi-element psychosocial intervention for early psychosis: results from the GET UP pragmatic cluster randomised controlled trial. | LitMetric
Antonio Lasalvia, MD PhD, UOC Psichiatria, Azienda Ospedaliera Universitaria Integrata (AOUI), Verona; Chiara Bonetto, PhD, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona; Jacopo Lenzi, PhD, Paola Rucci, PhD, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna; Laura Iozzino, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona; Massimo Cellini, Department of Mental Health, Az. USL Firenze, Firenze; Carla Comacchio, MD, Doriana Cristofalo, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona; Armando D'Agostino, MD, Department of Psychiatry, University of Milano, Milano; Giovanni de Girolamo, MD, IRCSS St John of God Clinical Research Centre of Brescia, Brescia; Katia De Santi, MD, UOC Psichiatria, Azienda Ospedaliera Universitaria Integrata (AOUI), Verona; Daniela Ghigi, MD, Department of Mental Health, Az. USL Rimini, Rimini; Emanuela Leuci, MD, Department of Mental Health, Az. USL Parma; Maurizio Miceli, MD, Department of Mental Health, Az. USL Firenze, Firenze; Anna Meneghelli, AO Ospedale Niguarda Ca' Granda Milano, MHD Programma2000, Milan; Francesca Pileggi, MD, Department of Mental Health, Az. USL Bologna, Bologna; Silvio Scarone, MD, Department of Psychiatry, University of Milano, Milano; Paolo Santonastaso, MD, Department of Neurosciences, University of Padova and Azienda Ospedaliera, Padova; Stefano Torresani, MD, Department of Mental Health, Az. USL Bolzano, Bolzano; Sarah Tosato, MD, PhD, Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona; Angela Veronese, MD, Department of Neurosciences, University of Padova and Azienda Ospedaliera, Padova; Angelo Fioritti, MD, Department of Mental Health, Az.USL Bologna, Bologna; Mirella Ruggeri, MD, UOC Psichiatria, Azienda Ospedaliera Universitaria Integrata (AOUI), Verona and Department of Neurosciences, Biomedicine and Movement Sciences, Section of Psychiatry, University of Verona, Verona, Italy.
Published: May 2017
AI Article Synopsis
Article Abstract
The GET UP multi-element psychosocial intervention proved to be superior to treatment as usual in improving outcomes in patients with first-episode psychosis (FEP). However, to guide treatment decisions, information on which patients may benefit more from the intervention is warranted.To identify patients' characteristics associated with (a) a better treatment response regardless of treatment type (non-specific predictors), and (b) a better response to the specific treatment provided (moderators).Some demographic and clinical variables were selected as potential predictors/moderators of outcomes at 9 months. Outcomes were analysed in mixed-effects random regression models. (Trial registration: ClinicalTrials.gov, NCT01436331)Analyses were performed on 444 patients. Education, duration of untreated psychosis, premorbid adjustment and insight predicted outcomes regardless of treatment. Only age at first contact with the services proved to be a moderator of treatment outcome (patients aged ⩾35 years had greater improvement in psychopathology), thus suggesting that the intervention is beneficial to a broad array of patients with FEP.Except for patients aged over 35 years, no specific subgroups benefit more from the multi-element psychosocial intervention, suggesting that this intervention should be recommended to all those with FEP seeking treatment in mental health services.
