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Potential molecular targets and pathways of a traditional Chinese medicine formula for bovine endometritis identified by network pharmacology.
Pol J Vet Sci
September 2024
Shanxi Key Lab. for Modernization of TCVM, College of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, China.
Bovine endometritis has become a persistent issue in the global dairy business, resulting in huge economic losses. Due to their numerous positive benefits, Chinese herbal medicines (CHMs) have recently demonstrated remarkable pharmacological potential against endometritis. The objective of this study was to investigate the effects and elucidate the underlying mechanisms of the Yimucao formula (YMF) that involves five herbs in lactation cows under endometritis conditions.
View Article and Find Full Text PDFTranscriptome analysis reveals heat shock protein 70 (HSP70) induced by tembusu virus infection is associated with immune responses.
Pol J Vet Sci
September 2024
Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, No. 50 Zhongling Street, Nanjing City, Jiangsu Province, 210014, PR China.
The outbreak and prevalence of tembusu virus (TMUV) endanger the breeding industry of waterfowls. However, little is known about the molecular mechanism underlying TMUV infection. It was reported that heat shock protein 70 (HSP70) was a positive regulator of the infection of TMUV.
View Article and Find Full Text PDFKeratinocyte exosomal LOC285194 ameliorates psoriasis by inhibiting the differentiation of CD4T cells to Th17 cells through regulating miR-211-5p/SIRT1 axis.
IUBMB Life
January 2025
Department of Dermatology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, People's Republic of China.
Keratinocytes exosome participates in the pathogenesis of psoriasis and exosomes always carry long non-coding RNAs (lncRNAs) into target cells to function as an essential immune regulator in psoriasis-related diseases. LncRNA LOC285194 is closely associated with the occurrence of psoriasis. However, whether keratinocyte exosomal LOC285194 participates in the process of psoriasis remains vague.
View Article and Find Full Text PDFStructural Repair of Reduced Graphene Oxide Promoted by Single-Layer Graphene.
Adv Sci (Weinh)
December 2024
Hefei National Research Center for Physical Sciences at the Microscale, Department of Materials Science and Engineering, School of Chemistry and Materials Science, Key Laboratory of Precision and Intelligent Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026, China.
High-temperature graphitization of graphene oxide (GO) is a crucial step for enhancing interlayer stacking and repairing the in-plane defects of reduced graphene oxide (rGO) films. However, the fine control of the structural repair and reducing the energy consumption in thermal treatment remain challenges. In this study, ab-initio molecular dynamics simulations combined with experiments are used to investigate the structural evolution of rGO upon thermal annealing, with or without the presence of single-layer graphene (SLG).
View Article and Find Full Text PDFHSP90 Family Members, Their Regulators and Ischemic Stroke Risk: A Comprehensive Molecular-Genetics and Bioinformatics Analysis.
Front Biosci (Schol Ed)
December 2024
Laboratory of Genomic Research, Research Institute for Genetic and Molecular Epidemiology, Kursk State Medical University, 305041 Kursk, Russia.
Background: Disruptions in proteostasis are recognized as key drivers in cerebro- and cardiovascular disease progression. Heat shock proteins (HSPs), essential for maintaining protein stability and cellular homeostasis, are pivotal in neuroperotection. Consequently, deepening the understanding the role of HSPs in ischemic stroke (IS) risk is crucial for identifying novel therapeutic targets and advancing neuroprotective strategies.
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