Association of angiotensin-converting enzyme, genes polymorphism with senile cataract.

Background: Senile cataract is the most common type of cataract characterized by gradual progressive thickening of the lens of the eye. Previously, many studies investigated the association between genetic polymorphism and senile cataract. Angiotensin-converting enzyme () I/D polymorphism is the potential risk factor for many eye-related diseases such as retinopathy and glaucoma. enzyme converts cholesterol to 24S-hydroxycholesterol; human lens' membranes contain the highest cholesterol content. Defects in enzymes of cholesterol metabolism can be associated with cataracts. Hence, the present study was carried out to investigate the association of and genes polymorphism with senile cataract cases and controls.

Materials And Methods: (rs 4646994) and (rs 754203) genes polymorphism in cases and controls were evaluated by polymerase chain reaction and restriction fragment length polymorphism.

Results: This study included 103 senile cataract cases (55 were males and 48 were females) and 102 controls (53 were males and 49 were females). Mean age of cases in this study was 52.02 ± 12.11 years while in control group 53.74 ± 11.87 years. Frequencies of ID, DD, and II genotypes in senile cataract cases were 64.07%, 4.85%, and 31.06% and controls were 61.76%, 26.47%, and 11.76%, respectively. The gene CT, CC, and TT genotype frequencies were 48.54%, 8.73%, and 42.71% in senile cataract cases and 28.43%, 3.92%, and 67.64% in healthy controls, respectively. DD and II genotypes ( < 0.001,P = 0.0008) and CT and TT genotypes ( = 0.003,P = 0.0003) were significantly associated with senile cataract cases compared to the controls.

Conclusion: Findings of this study suggest that and genes polymorphism may be a predictive marker for early identification of population at risk of senile cataract. This potential role of and genes polymorphism as a marker of susceptibility to senile cataract needs further validation in studies involving larger number of patients from different regions.