AI Article Synopsis

  • - The case involves congenital hypertrichosis linked to a duplication of the FOXN1 gene, which is located on chromosome 17 and crucial for hair growth regulation.
  • - FOXN1 is part of the forkhead box gene family, playing an important role in the differentiation of epithelial cells and specifically keratinocytes related to hair.
  • - This report is significant as it is the first documented instance of FOXN1 duplication being associated with congenital hypertrichosis in scientific literature.

Article Abstract

We report a case of congenital hypertrichosis and FOXN1 duplication. FOXN1 is a member of the forkhead box gene family, located on chromosome 17. Its function includes differentiation of epithelial cells and regulation of keratinocytes, especially hair keratins. Loss of function of these transcription factors leads to a disruption in hair growth. As far as we are aware, this is the first case of FOXN1 duplication associated with congenital hypertrichosis to be reported in the literature.

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http://dx.doi.org/10.1111/pde.13078DOI Listing

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Article Synopsis
  • - The case involves congenital hypertrichosis linked to a duplication of the FOXN1 gene, which is located on chromosome 17 and crucial for hair growth regulation.
  • - FOXN1 is part of the forkhead box gene family, playing an important role in the differentiation of epithelial cells and specifically keratinocytes related to hair.
  • - This report is significant as it is the first documented instance of FOXN1 duplication being associated with congenital hypertrichosis in scientific literature.
View Article and Find Full Text PDF

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