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Tangled but ordered human mitochondrial tRNA maturation.
Sci China Life Sci
January 2025
Key Laboratory of RNA Innovation, Science and Engineering, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
Background: Janus kinase II (JAK 2) mutation plays a critical part in the pathophysiology of myeloid pathologies and has been presented to be tangled in thrombotic obstacles of these sicknesses. This study documents the prevalence of JAK 2 v617 mutations in malignant and non-malignant tumors in the Eastern province of the Kingdom of Saudi Arabia.
Methods: A total of 112 patients were included in the current study between June 2022 and May 2023 at the Molecular Biology Laboratory of the King Fahad Hospital of the University, AlKhobar, Saudi Arabia.
Phylogenomic analyses unravel the tangled evolutionary history of Genisteae (Fabaceae).
Mol Phylogenet Evol
November 2024
Department of Integrative Biology, University of Texas at Austin, Austin, TX, USA.
Article Synopsis
- Genisteae is a tribe in the legume family Fabaceae known for producing quinolizidine alkaloids that help resist pests, but its generic relationships remain unclear due to a lack of modern studies.
- Previous research identified three main clades within Genisteae: Lupinus, Cytisus-Genista, and Argyrolobium, with ongoing debates about the classification of certain genera like Teline and Chamaecytisus.
- Recent phylogenomic analysis, using extensive data from 24 of the tribe's 25 genera, revealed four significant clades within Genisteae, clarified the placement of Teline and Sellocharis, and supported the transfer of the Argyrolobium group into Gen
Emerging Trends and Technologies Used for the Identification, Detection, and Characterisation of Plant-Parasitic Nematode Infestation in Crops.
Plants (Basel)
October 2024
Centre for Crop Health, University of Southern Queensland, Toowoomba, QLD 4305, Australia.
Accurate identification and estimation of the population densities of microscopic, soil-dwelling plant-parasitic nematodes (PPNs) are essential, as PPNs cause significant economic losses in agricultural production systems worldwide. This study presents a comprehensive review of emerging techniques used for the identification of PPNs, including morphological identification, molecular diagnostics such as polymerase chain reaction (PCR), high-throughput sequencing, meta barcoding, remote sensing, hyperspectral analysis, and image processing. Classical morphological methods require a microscope and nematode taxonomist to identify species, which is laborious and time-consuming.
View Article and Find Full Text PDFArchaic introgression contributed to shape the adaptive modulation of angiogenesis and cardiovascular traits in human high-altitude populations from the Himalayas.
Elife
November 2024
Laboratory of Molecular Anthropology and Centre for Genome Biology, Department of Biological, Geological and Environmental Sciences, University of Bologna, Bologna, Italy.
Article Synopsis
- Previous studies have shown that some human populations mixed with extinct species, influencing their ability to adapt to different environmental challenges through a process known as adaptive introgression.
- A key example involves a gene that helps Himalayan highlanders resist chronic mountain sickness, which was passed down from Denisovans through this gene flow.
- This research used advanced genetic analysis methods to identify multiple genes that have contributed to specific adaptations in Tibetan and Sherpa populations, particularly in their capacity to manage low oxygen levels at high altitudes.
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