AI Article Synopsis
- Cardiosphere-derived cells (CDCs) have shown potential in reducing scar tissue and enhancing heart muscle viability in patients with myocardial infarction, and preliminary studies suggest benefits in non-ischaemic dilated cardiomyopathy (DCM).
- In a study using a canine model, researchers infused 30 million allogeneic CDCs from a donor dog into Doberman pinschers affected by spontaneous DCM.
- The infusion process was safe, with no adverse events observed, and subsequent heart tissue analysis indicated no signs of immune rejection of the transplanted cells.
Article Abstract
Cardiosphere-derived cells (CDCs) have been shown to reduce scar size and increase viable myocardium in human patients with mild/moderate myocardial infarction. Studies in rodent models suggest that CDC therapy may confer therapeutic benefits in patients with non-ischaemic dilated cardiomyopathy (DCM). We sought to determine the safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM. Canine CDCs (cCDCs) were grown from a donor dog heart. Similar to human CDCs, cCDCs express CD105 and are slightly positive for c-kit and CD90. Thirty million of allogeneic cCDCs was infused into the coronary vessels of Doberman pinscher dogs with spontaneous DCM. Adverse events were closely monitored, and cardiac functions were measured by echocardiography. No adverse events occurred during and after cell infusion. Histology on dog hearts (after natural death) revealed no sign of immune rejection from the transplanted cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543505 | PMC |
| http://dx.doi.org/10.1111/jcmm.13077 | DOI Listing |
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