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Effect of cyclosporin A on an experimental chronic viral infection of the central nervous system.
J Neuroimmunol
January 1989
Laboratoire de Neurovirologie, INSERM U 56, Hôpital de Bicêtre, France.
The effects of cyclosporin A (CsA) on neuropathological lesions induced by a chronic viral infection have been tested in the experimental model of the mouse hepatitis virus 3 (MHV3) infection. Daily injections of CsA (50 mg/kg) inhibited the expression of the MHV3-induced ependymitis, meningitis, hydrocephalus and vasculitis. The effect was preserved even if CsA treatment was initiated 15 days after virus infection but was lost if CsA treatment was given later on or for a shorter period of time.
View Article and Find Full Text PDFEffect of cyclosporin A on MHV3-induced chronic CNS infection in mice.
Adv Exp Med Biol
March 1988
INSERM U 56, Hôpital de Bicêtre, France.
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