AI Article Synopsis
- A rare case of concomitant confluent and reticulated papillomatosis (CRP) and acanthosis nigricans (AN) was observed in a 12-year-old obese Japanese girl, highlighting the intersection of these two skin conditions.
- Oral minocycline therapy, typically effective for CRP, also showed results in improving both CRP and obesity-related AN in this patient.
- The study discusses mechanisms for minocycline's effectiveness and reviews literature linking CRP and obesity-associated AN, suggesting they may share common underlying causes or mechanisms.
Article Abstract
Concomitant confluent and reticulated papillomatosis (CRP) and acanthosis nigricans (AN) is rare. We present a case of concomitant CRP and obesity-associated AN in a 12-year-old obese Japanese girl. Curiously, oral minocycline therapy, which has been shown to be effective for CRP, was effective against both CRP and AN. Possible mechanisms by which minocycline could have improved skin lesions of CRP and obesity-associated AN are discussed. In addition, reports of concomitant CRP and obesity-associated AN are reviewed. CRP and obesity-associated AN share common clinicopathological features and some reports have described concomitant CRP and obesity-associated AN. Together with the observation that skin lesions of CRP and obesity-associated AN in the present case responded to oral minocycline therapy, these facts suggest a tight relationship or a common pathogenetic pathway between these pathologies.
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| http://dx.doi.org/10.1111/1346-8138.13819 | DOI Listing |
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