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Knee osteoarthritis (KOA) is a healthcare burden affecting over 595 million people worldwide. Recently, intra-articular platelet-rich plasma (PRP) injections from the patient's blood have shown promise in slowing KOA progression due to platelets' regenerative properties. This study aimed to evaluate the optimal dosing and schedule for PRP therapy in managing mild to moderate KOA.
View Article and Find Full Text PDFPesticide exposure and sleep disorder: A cross-sectional study among Thai farmers.
Heliyon
January 2025
Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Pesticide exposure might be an important risk factor for sleep disorders, however current epidemiological evidence is limited. The main objective of this study was to determine the association between historical use of pesticides and sleep disorders. Data on the historical use of 38 individual pesticides of almost thirty thousand Thai farmers were collected using questionnaire method.
View Article and Find Full Text PDFGWAS analysis revealed genomic loci and candidate genes associated with the 100-seed weight in high-latitude-adapted soybean germplasm.
Theor Appl Genet
January 2025
Research Center for Life Sciences Computing, Zhejiang Lab, Hangzhou, 310012, China.
In the present study, we identified 22 significant SNPs, eight stable QTLs and 17 potential candidate genes associated with 100-seed weight in soybean. Soybean is an economically important crop that is rich in seed oil and protein. The 100-seed weight (HSW) is a crucial yield contributing trait.
View Article and Find Full Text PDFTreatment outcomes and prognostic factors in patients with colorectal cancer and synchronous lung metastases in the conversion therapy era.
Int J Colorectal Dis
January 2025
Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Purpose: The Japanese Grade Classification based on the status of pulmonary and mesenteric nodal metastases and the presence of extrapulmonary metastases had a prognostic value in patients with colorectal lung metastases previously. Because the survival of such patients has improved in the era of conversion therapy, this classification needs to be reaudited.
Methods: This study reviewed the treatment sequences of 126 colorectal cancer patients with synchronous lung metastases between 2010 and 2022 at our hospital.
Strategic SWOT analysis of the University of Nigeria Teaching Hospital using Modified Delphi Technique: implications for strengthening national and regional health systems.
BMC Health Serv Res
January 2025
Department of Medicine, College of Medicine, University of Nigeria Teaching Hospital Ituku-Ozalla, Enugu, Nigeria.
Background And Aim: The perennial underperformance of the Nigerian Health System necessitated enhanced advocacy for health to be placed at the centre of a renewed social contract and as a means of bolstering public trust. The hospital management of the University of Nigeria Teaching Hospital (UNTH) introduced initiatives to improve the hospital's operational environment and service performance in response to the population served. Following these changes, an Organizational Capacity Assessment (OCA) is critical to direct further development in the organization.
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