Aim: To explore the association between () infection status, intestinal metaplasia (IM), and colorectal adenomas.
Methods: We retrospectively reviewed 1641 individuals aged ≥ 40 years who underwent physical examination, laboratory testing, C-urea breath testing, gastroscopy, colonoscopy, and an interview to ascertain baseline characteristics and general state of health. Histopathological results were obtained by gastric and colorectal biopsies.
Results: The prevalence of infection and adenomas was 51.5% (845/1641) and 18.1% (297/1641), respectively. infection was significantly correlated with an increased risk of colorectal adenomas (crude OR = 1.535, 95%CI: 1.044-1.753, = 0.022; adjusted OR = 1.359, 95%CI: 1.035-1.785, = 0.028). Individuals with IM had an elevated risk of colorectal adenomas (crude OR = 1.664, 95%CI: 1.216-2.277, = 0.001; adjusted OR = 1.381, 95%CI: 0.998-1.929, = 0.059). Stratification based on infection stage and IM revealed that IM accompanied by infection was significantly associated with an increased risk of adenomas (crude OR = 2.109, 95%CI: 1.383-3.216, = 0.001; adjusted OR = 1.765, 95%CI: 1.130-2.757, = 0.012).
Conclusion: -related IM is associated with a high risk of colorectal adenomas in Chinese individuals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5330829 | PMC |
| http://dx.doi.org/10.3748/wjg.v23.i8.1443 | DOI Listing |
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