The proteins that regulate cell proliferation, metastatic potential, survival in circulation, and immune evasion represent most of the targets for therapeutic intervention in cancer. Furthermore, genomic profiling of just the cancer cells leaves critical information about the tumor microenvironment in the dark. The articles highlighted in this Focus Issue describe efforts to translate genomic data into knowledge of aberrant signaling that can be therapeutically targeted and strategies to explore not only the changes that occur in the protein landscape of the tumors but also in the protein profiles of the tumor microenvironment.
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| http://dx.doi.org/10.1126/scisignal.aan0430 | DOI Listing |
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Nutrition and Hypertension Researches in 2023: focus on salt intake and blood pressure.
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Hypertension is a major global health issue that contributes significantly to cardiovascular morbidity and mortality. The management and prevention of hypertension often involve nutritional and dietary modifications, which are considered effective non-pharmacological strategies. In 2023, the Hypertension Research published several papers highlighting nutrition and hypertension.
View Article and Find Full Text PDF"To Whom Should I Refer Her?" Factors Contributing to Religious Informal Helpers' Referral Decisions for Women with Mental Illness and At-Risk Women: The Case of Israeli Balaniyot.
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School of Social Work, Hadassah Academic College, Jerusalem, Israel.
Religious informal helpers may play a crucial role in recognizing and providing referrals to mental health professional for at-risk individuals, including those with mental illness, especially since members of religious communities tend to conceal their difficulties and to view religious leaders as a sole source of assistance. This quantitative study aimed to explore Jewish bathhouse attendants ("balaniyot") who assist women in their monthly immersion, a unique situation in which mental health symptoms (e.g.
View Article and Find Full Text PDFExploring condition in which people accept AI over human judgements on justified defection.
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College of Policy Studies, Tsuda University, Tokyo, 151-0051, Japan.
As artificial intelligence (AI) technology is introduced into different areas of society, understanding people's willingness to accept AI decisions emerges as a critical scientific and societal issue. It is an open question whether people can accept the judgement of humans or AI in situations where they are unsure of their judgement, as in the trolley problem. Here, we focus on justified defection (non-cooperation with a bad person) in indirect reciprocity because it has been shown that people avoid judging justified defection as good or bad.
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View Article and Find Full Text PDFBrain State Forecasting for Precise Brain Stimulation: Current Approaches and Future Perspectives.
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January 2025
Center for Mind/Brain Sciences (CIMeC), University of Trento, 38068, Rovereto, (TN), Italy.
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