Recent studies suggest revisions to the SNARE paradigm of membrane fusion. Membrane tethers and/or SNAREs recruit proteins of the Sec 1/Munc18 family to catalyze SNARE assembly into -complexes. SNARE-domain zippering draws the bilayers into immediate apposition and provides a platform to position fusion triggers such as Sec 17/α-SNAP and/or synaptotagmin, which insert their apolar "wedge" domains into the bilayers, initiating the lipid rearrangements of fusion.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349777 | PMC |
| http://dx.doi.org/10.1091/mbc.E16-07-0517 | DOI Listing |
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