Obesity is a major health crisis resulting in comorbidities such as hypertension, type 2 diabetes, and obstructive sleep apnea. The need for safe and efficacious drugs to help assist with weight loss and reduce cardiometabolic risk factors is great. With several FDA-approved drugs on the market, there is still a great need to develop long-term obesity treatments or noninvasive oral agents to help assist individuals with obesity when used in conjunction with lifestyle modifications.
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Universidad de Caldas, Manizales, Colombia.
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View Article and Find Full Text PDFThe Sir Ludwig Guttmann lecture 2023: psychosocial factors and adjustment dynamics after spinal cord injury.
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January 2025
Rehabilitation Studies, Faculty of Medicine and Health, The University of Sydney, The Kolling Institute, Northern Sydney Local Health District, St Leonards, NSW, Australia.
Study Design: Narrative review OBJECTIVES: Sir Ludwig Guttmann realised spinal cord injury (SCI) rehabilitation should incorporate more than a biomedical approach if SCI patients were to adjust to their injury and achieve productive social re-integration. He introduced components into rehabilitation he believed would assist his patients build physical strength as well as psychological resilience that would help them re-engage with their communities. We pay tribute to Sir Ludwig by presenting research that has focussed on psychosocial factors that contribute to adjustment dynamics after SCI.
View Article and Find Full Text PDFEmergency psychology is a branch of psychology that, although it began several years ago due to dramatic events around the world, is increasingly being established in the day-to-day work of the emergency department. Due to the very specific nature of this type of intervention, it is essential that, in addition to proper training and experience, emergency psychologists have a series of competencies. In this study, we developed a questionnaire, the Crisis and Emergency Intervention Skills Scale (CEISS), ad hoc for this research, and we determined the relationship of the CEISS score with the most relevant competencies.
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T cell exhaustion is a state of dysfunction that can occur due to persistent exposure to antigens, such as in the tumor microenvironment. The progressive loss of effector functions in exhausted T cells can lead to resistance to immune checkpoint inhibitors and adoptive cell immunotherapies. Improving our understanding of the exhaustion process is thus crucial for optimizing the clinical outcomes of immunotherapy.
View Article and Find Full Text PDFRapid determination of etomidate and its structural analogues in e-liquid by probe electrospray ionization quadrupole time-of-flight mass spectrometry.
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Key Laboratory of Forensic Medicine, Ministry of Justice, Shanghai Forensic Service Platform, Shanghai Key Laboratory of Forensic Science, Academy of Forensic Science, Guangfu West Road 1347, Shanghai 200063, China. Electronic address:
Etomidate and its structural analogues, which have anesthetic effects, are classified as controlled psychotropic drugs. Electronic cigarettes (e-cigarettes) have become more and more popular. With the increase of adding etomidate and its analogues to electronic liquids (e-liquids), there is a trend of abuse, which is a tough problem urgently need to be solved.
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