Mandibular swellings may occur as a result of many benign lesions of odontogenic or non-odontogenic origin. Ameloblastomas are benign tumours of odontogenic origin, whose importance lies in its potential to grow into enormous size with resulting bone deformity, it is a slow-growing, persistent, and locally aggressive neoplasm. The unicystic ameloblastoma (UA) represents an ameloblastoma variant, presenting as a cyst clinically and radiographically, but showing typical ameloblastomatous epithelium lining histologically. It commonly occurs in second and third decades of life and is rare in children under 12 years of age, and better response to conservative treatment. It shares many clinical and radiographic features with odontogenic cysts/tumours and/or periapical disease of endodontic origin. Reported here is an unusual case of unicystic ameloblastoma involving the crown of an unerupted mandibular first premolar in a 9-year boy in an uncommon location, which was misdiagnosed as periapical lesion of inflammatory origin clinically, and as a dentigerous cyst radiographically. This highlights the importance to routinely submit the removed surgical specimen for histopathological examination.
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Head Neck Pathol
December 2024
Institute of Pathology, Sheba Medical Center, Tel Hashomer, 5265601, Israel.
Purpose: Current standard of care for ameloblastoma (conventional/unicystic - mural type) usually mandates extensive bone resection that frequently necessitates immediate reconstruction with serious sequelae, especially among young patients. BRAF-mutated ameloblastomas can be targeted by BRAF inhibitors to markedly reduce their size, enabling conservative removal of residual tumor. We aimed to characterize the effect of post-treatment histomorphologic changes.
View Article and Find Full Text PDFAppl Immunohistochem Mol Morphol
November 2024
Department of Basic Sciences, College of Dentistry, Princess Nourah bint Abdulrahman University, 84428, Riyadh 11671, Saudi Arabia.
Odontogenic cysts and tumors exhibit a broad spectrum of biological characteristics. Despite recent advances in understanding the complex nature of these lesions, relatively less is known about the molecular markers involved in key pathogenic steps, such as proliferation and differentiation. This study aimed to elucidate the expression patterns of p63 and Ki-67 in odontogenic lesions, which may influence the management strategies.
View Article and Find Full Text PDFIndian J Otolaryngol Head Neck Surg
December 2024
Department of Oral Medicine and Radiology, Government Dental College and Hospital, Srinagar, India.
Glandular odontogenic cysts(GOC) are among the rarest odontogenic cysts defined by the presence of glandular epithelium in the epithelial lining posing some diagnostic difficulties. GOC associated with ameloblastoma is extremely rare with only 5 cases reported. This report deals with this rare occurrence of GOC along with unicystic ameloblastoma.
View Article and Find Full Text PDFSemin Diagn Pathol
November 2024
Professor and Head, Department of Oral Pathology & Microbiology, King George's Medical, University, Lucknow 226003, UP, India. Electronic address:
Ameloblastoma is a true benign odontogenic epithelial tumor, primarily arising in the jaw, and ranks as the second most prevalent odontogenic neoplasm following odontoma. Known for its diverse clinical, radiographic, and histological manifestations, ameloblastoma encompasses a wide spectrum of presentations. Unicystic ameloblastomas (UAs), a less common and generally less aggressive variant, appear as cystic lesions that can mimic ordinary jaw cysts in their clinical and radiologic features.
View Article and Find Full Text PDFCase Rep Dent
October 2024
Department of Oral and Maxillofacial Surgery, Postgraduate Studies and Research Division (DEPeI), Faculty of Dentistry, Universidad Nacional Autónoma de México, Mexico City, Mexico.
The most common odontogenic tumor is the solid ameloblastoma. This is concerning due to the progressive bone destruction in its intraosseous variant; this type of pathology often gets a delayed diagnosis due to the asymptomatic characteristic it has. The aim of the article is to propose a conservative treatment for multicystic ameloblastoma, reviewing the latest concepts, controversies, and treatment options described in the literature.
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