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Clinicopathological diagnosis of axillary signet-ring cell-like/histiocytoid carcinoma: a case report and literature review.
Histol Histopathol
October 2024
Department of Pathology, Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, PR China.
Objective: To explore the clinicopathological and morphological characteristics, diagnosis, differential diagnosis, treatment, and prognosis of primary signet-ring cell/histiocytoid carcinoma (SRCHC) of the axilla.
Methods: The clinical manifestations, pathomorphological characteristics, and immunohistochemical staining results of a case of primary SRCHC in the axilla were retrospectively analyzed, and the relevant literature was reviewed.
Results: The patient was a 69-year-old male.
Myxoid variant of plexiform fibrohistiocytic tumor: case report.
AME Case Rep
May 2024
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Background: Plexiform fibrohistiocytic tumor (PFH) is a rarely metastasizing slowly growing neoplasm usually affecting children and young adults. The tumor usually has a dermal-subcutaneous location, is poorly circumscribed, and is comprised of a plexiform or multinodular proliferation of a variable admixture of fibroblasts and histiocytoid cells with a distinctive biphasic morphology. Myxoid change in PFH is extremely rare with only five cases of myxoid variant of PFH reported to date in the English literature.
View Article and Find Full Text PDFSweet Syndrome: Clinical Presentation, Malignancy Association, Autoinflammatory Disorders and Treatment Response in a Cohort of 93 Patients with Long-term Follow-up.
Acta Derm Venereol
December 2023
Department of Dermatology, Hospital Clínic de Barcelona, Universitat de Barcelona, Spain.
Article Synopsis
- Sweet syndrome is a skin condition linked to various medical issues, with a study in Spain analyzing 93 patients from 2001 to 2021 to uncover its characteristics and associations with malignancy and other disorders.* -
- The majority of cases were either idiopathic, associated with malignancies like acute myeloid leukaemia, or reactive to infections, with specific symptoms and histological types identified, showing that pain and nodules relate to subcutaneous-Sweet syndrome.* -
- Key findings indicate that male sex, fever, and other clinical factors are linked to malignancy in Sweet syndrome patients, suggesting that careful monitoring and a 6-month follow-up are important for those experiencing relapses, especially with myelodys
Neoplastic or inflammatory? A case report of Sweet syndrome with CD30+ cells in a patient with B-lymphoblastic leukemia.
J Cutan Pathol
December 2023
Department of Pathology, Rush University Medical Center, Chicago, Illinois, USA.
CD30+ cells are typically part of lymphoproliferative disorders but can also be seen in inflammatory dermatoses. We present a case of 47-year-old man with a history of B-lymphoblastic leukemia (B-ALL) who presented with fever, leukocytosis, and papulonodular skin lesions, involving the extremities and trunk. A punch biopsy specimen demonstrated papillary dermal edema with a neutrophilic and histiocytic infiltrate extending into the subcutis.
View Article and Find Full Text PDFGiant Cell Tumors With HMGA2::NCOR2 Fusion : Clinicopathologic, Molecular, and Epigenetic Study of a Distinct Entity.
Am J Surg Pathol
July 2023
Department of Biopathology, Institut Bergonié, Comprehensive Cancer Center, Bordeaux, France.
Giant cell tumors (GCTs) with high mobility group AT-Hook 2 ( HMGA2 )::nuclear receptor corepressor 2 ( NCOR2 ) fusion are rare mesenchymal tumors of controversial nosology, which have been anecdotally reported to respond to CSFR1 inhibitors. Here, we performed a comprehensive study of 6 GCTs with HMGA2::NCOR2 fusion and explored their relationship with other giant cell-rich neoplasms. Tumors occurred in 4 females and 2 males ranging in age from 17 to 32 years old (median 24).
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