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Emerging trends in long-acting sustained drug delivery for glaucoma management.
Drug Deliv Transl Res
January 2025
School of Pharmacy, Medical Biology Centre, Queen's University Belfast, Belfast, UK.
Glaucoma is an optic neuropathy in which progressive degeneration of retinal ganglion cells and the optic nerve leads to irreversible visual loss. Glaucoma is one of the leading causes of blindness. The pathogenesis of glaucoma is determined by different pathogenetic mechanisms, including increased intraocular pressure, mechanical stress, excitotoxicity, resistance to aqueous drainage and oxidative stress.
View Article and Find Full Text PDFEfficacy of 0.5% doxepin in coconut oil applied topically for chronic refractory pruritus: a case series from the VA Palo Alto Health Care System.
Arch Dermatol Res
January 2025
Department of Dermatology, Stanford University School of Medicine, 450 Broadway Street Pavilion B, 4th Floor, Redwood City, CA, 94063, USA.
Utilization and prescription patterns of topical steroids: a study at dessie comprehensive specialized hospital, Ethiopia.
Arch Dermatol Res
January 2025
Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Background: Topical steroids are widely used in dermatology for their anti-inflammatory and immunosuppressive effects, but misuse can cause skin thinning and systemic issues. In Ethiopia, where skin conditions are common, understanding how topical steroids are prescribed and used is essential for ensuring their safe and effective use.
Objective: The study aimed to assess topical steroids' prescription and utilization pattern in Dessie Comprehensive Specialized Hospital (DCSH) from February 1 to May 30, 2024.
Purpose: Although fluoride is known to be effective and safe, an increasing number of parents refuse to allow fluoride applications for their children. This study aimed to compare the parents who accepted and rejected fluoride application for their children in terms of their attitudes toward fluoride and vaccinations, sociodemographic characteristics, and source of knowledge.
Materials And Methods: In this cross-sectional study, a previously validated questionnaire was administered to 85 parents who did not consent to have topical fluoride applied to their children's teeth (AF group) and the 143 parents who consented to have it applied (F group) in a pediatric dentistry clinic.
CD4+ T helper 2 cell-macrophage crosstalk induces IL-24-mediated breast cancer suppression.
JCI Insight
January 2025
Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Krantz Family Center for Cancer Research, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
CD4+ T cells contribute to antitumor immunity and are implicated in the efficacy of cancer immunotherapies. In particular, CD4+ T helper 2 (Th2) cells were recently found to block spontaneous breast carcinogenesis. However, the antitumor potential of Th2 cells in targeting established breast cancer remains uncertain.
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