Purpose: To analyse whether the screening performance parameters of the Maltese National Breast Screening Programme first screening round met requirements set by European standards. The association between screening age and results of screening performance parameters was also investigated.
Method: Quantitative methodology was used to review examinations of women who were recalled for a technical recall or further assessment rates. All accessible members of the population recalled during the first round were retrospectively reviewed resulting in a sample of 2300 recalled examinations.
Results: Malta's first screening round met the European Guidelines recommendations for technical repeat rate (0.26%), early recall rate (0.45%), breast cancer detection rate (13.77 per 1000 women) and Positive Predictive Value of screening test (7.58%). However, local recall rate (18.53%) and further assessment rate (18.27%) were higher than recommended. The Chi square test showed a statistically significant difference (p ≤ 0.05) in recall rates between the compared age groups, as younger women (51-55 years) were more likely to have a negative diagnosis after the initial mammogram whereas older women (56-60 years) were more likely to be recalled. There was no age discrepancy (p ≥ 0.05) in local breast cancer detection rate and positive predictive value of screening test.
Conclusion: Although the Maltese first screening round performed well, this study found deficiencies in recall and further assessment rates, which according to literature may result in psychological morbidity and inefficient use of screening resources. This study also concluded that when a cohort is analysed, age is not as significant as the screening round itself (first/subsequent).
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.radi.2016.09.008 | DOI Listing |
Biotechnol Prog
March 2025
Centre for Synthetic Biology, Imperial College London, London, UK.
The quality control of RNA has become increasingly crucial with the rise of mRNA-based vaccines and therapeutics. However, conventional methods such as LC-MS often require specialized equipment and expertise, limiting their applicability to high throughput experiments. Here, we optimize a previously characterized RNA integrity biosensor, that provides a simple colorimetric output, using Design of Experiments (DoE).
View Article and Find Full Text PDFVet Pathol
March 2025
Universidade Federal do Mato Grosso do Sul, Campo Grande, Brazil.
Different tissues have a normal color spectrum that reflects their cellular composition and/or metabolic features. Similarly, distinct color variations may occur in tissues that have undergone pathologic or nonpathologic changes. Common examples of color changes in domestic animal tissues include red (associated with erythrocytes, hemoglobin, and myoglobin), brown (ferric hemoglobin or myoglobin, suppurative inflammation, lipid oxidation, postmortem autolysis, formalin fixation, neoplasms arising from cytochrome-rich tissues), yellow (hemoglobin and iron degradation, biliary pigment and by-products, carotenes, keratin, necrosis, suppurative or fibrinous inflammation), green (hemoglobin and iron degradation, biliary pigment and by-products, meconium, eosinophilic or suppurative inflammation, oomycete and algal infections), white (lack of blood, adipose tissue and its neoplasms, chylous effusion, necrosis, mineralization, fibrosis, lymphoid tissue, round cell neoplasms), translucent (transudate, cysts), black to gray (hemoglobin and iron degradation, melanin, carbon, tattoos), and blue to purple (poorly oxygenated blood, tattoos).
View Article and Find Full Text PDFActas Esp Psiquiatr
March 2025
Psychiatry Unit, Polyclinic Hospital University of Messina, 98125 Messina, Italy; Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, 98125 Messina, Italy.
Background: Recent developments have highlighted the importance of separation anxiety across the lifespan, positioning it as a longitudinal psychopathological dimension. Few studies in the past decade, have explored this correlation within the context of other psychiatric disorders. This study aims to assess the presence of childhood and adulthood separation anxiety in a sample of adults with personality disorders, and its potential contribution to specific personality domains.
View Article and Find Full Text PDFJ Chem Inf Model
March 2025
Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Drug cocrystallization is a powerful strategy to enhance drug properties by modifying their physicochemical characteristics without altering their chemical structure. However, the identification of suitable coformers remains a challenging and resource-intensive task. To streamline this process, we developed a novel cocrystal prediction model, Cocry-pred, which utilizes the Network-Based Inference (NBI) algorithm─a dynamic resource propagation method─to recommend coformers for target molecules based on topological data from cocrystal network and molecular substructure information.
View Article and Find Full Text PDFMedicine (Baltimore)
March 2025
Department of Medical Education, Faculty of Medicine, Izmir Democracy University, Izmir, Turkey.
Concerns about the appearance of teeth and mouth, which play a key role in communication and first impressions, are natural to some extent. However, excessive concern over these areas should raise suspicion of body dysmorphic disorder (BDD). The use of a validated and standardized screening tool in dental settings may improve the identification of BDD.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!