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Pre-biologic disease trajectories are associated with morbidity burden and biologic treatment response in severe asthma.
Eur Respir J
January 2025
Department of Respiratory Medicine, Copenhagen University Hospital - Bispebjerg, Copenhagen, Denmark
Background: Biologics can induce remission in some patients with severe asthma, however, little is known about pre-biologic disease trajectories and their association with outcomes from biological treatment. We aimed to identify long-term trajectories of disease progression in patients initiating biologics and investigate trajectory associations with disease burden and impact on biologic therapy efficacy.
Methods: Patients in the Danish Severe Asthma Registry initiating biologic therapy between 2016-2022 were included and followed retrospectively in prescription databases starting 1995.
Changes in immature granulocyte levels and their association with disease activation following biologic therapy in patients with ankylosing spondylitis.
Reumatol Clin (Engl Ed)
December 2024
Kahramanmaraş Sütçü İmam University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Turkey.
Introduction: AS is a chronic disease with an inflammatory serum microenvironment characterized by increased oxidative stress (OS). Along with OS, reactive oxygen species (ROS) are elevated in patients with AS. Overexpression of ROS causes active inflammatory processes leading to the secretion of pro-inflammatory factors, including tumor necrosis factor-alpha (TNF-α).
View Article and Find Full Text PDFLongitudinal Assessment of Glucocorticoid Toxicity Reduction in Patients With Severe Asthma Treated With Biologic Therapies.
J Allergy Clin Immunol Pract
October 2024
Wellcome-Wolfson Centre for Experimental Medicine, School of Medicine, Dentistry, and Biological Sciences, Queen's University Belfast, Belfast, United Kingdom; Department of Respiratory Medicine, Belfast City Hospital, Belfast Health and Social Care Trust, Belfast, United Kingdom.
Background: Toxicities associated with oral corticosteroids (OCS) are well described. Targeted biologics for severe asthma (SA) substantially reduce OCS exposure with the potential to reduce cumulative OCS-related toxicities. The Glucocorticoid Toxicity Index (GTI) systematically assesses OCS-related toxicity; the GTI Aggregate Improvement Score (AIS) is a bidirectional measure of total toxicity change with a minimal clinically important difference (MCID) of ≤-10.
View Article and Find Full Text PDFImpact of the pre-biologic treatment journey on biologic drug survival in psoriasis: A nationwide cohort study.
J Eur Acad Dermatol Venereol
July 2024
Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Article Synopsis
- - The study aimed to determine how a patient's treatment journey before starting biologic drugs affects the durability of those treatments for psoriasis, utilizing data from Danish national registries over a period from 2010 to 2021.
- - 2496 patients were analyzed, with a majority on adalimumab, and results showed that about 78.2% discontinued treatment during an average follow-up of 5 years.
- - Ultimately, the study concluded that the complexity of the pre-biologic treatment journey did not have a significant impact on the survival rate of biologic drugs in these patients.
Exploring Definitions and Predictors of Response to Biologics for Severe Asthma.
J Allergy Clin Immunol Pract
September 2024
Observational and Pragmatic Research Institute, Singapore; Optimum Patient Care Global, Cambridge, United Kingdom; Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom. Electronic address:
Background: Biologic effectiveness is often assessed as response, a term that eludes consistent definition. Identifying those most likely to respond in real-life has proven challenging.
Objective: To explore definitions of biologic responders in adults with severe asthma and investigate patient characteristics associated with biologic response.
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