AI Article Synopsis
- The study explores the relationship between serotonin receptors and cannabinoid systems in the brain, focusing on how 5-HT1 receptors in the accumbens shell (Acb shell) influence memory deficits caused by a cannabinoid agonist, ACPA, in male Wistar rats.
- Using a test-retest method on an elevated plus-maze, researchers implanted cannulae to administer different substances and found that ACPA and the 5-HT1 receptor agonist CP94253 increased open-arms time, indicating memory deficits.
- The results indicate that activation or blockage of the 5-HT1 receptors in the Acb shell does not significantly impact memory deficits induced by ACPA, suggesting these receptors
Article Abstract
Background: Some studies have indicated a close relation between serotonergic and cannabinoidergic systems in several brain regions. Thus, the aim of current study is investigating the effect of 5-HT1 receptors of accumbens shell (Acb shell) on aversive memory deficit induced by ACPA (cannabinoid CB1 receptor agonist) using test-retest protocol of elevated plus-maze (EPM) in male Wistar rats.
Method: Bilateral guide cannulae were implanted to allow microinjection of ACPA, CP94253 HCL (5-HT1 receptor agonist agonist) or GR127935 HCL (5-HT1 receptor antagonist).
Results: Post-test intra-Acb shell of ACPA (0.002 μg/rat), CP94253 (0.5 and 5 ng/rat) and GR127935 (5 ng/rat) increased the percentage of open-arms time (%OAT) in the EPM task compared to the control group, indicating aversive memory deficit. Moreover, concurrent microinjection of the subthreshold dose of CP94253 and GR127935 into Acb shell did not alter open-arms exploratory behavior induced by intra-Acb shell of ACPA on the retest day.
Conclusion: Our data suggests that Acb shell 5-HT1 receptor does not affect aversive memory deficit induced by ACPA in the Acb shell.
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