Interferon-I: The Pièce de Résistance of HIV-1 Transmission?

Trends Microbiol

Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. Electronic address:

Published: May 2017

Despite the extensive viral quasispecies that develops in an individual during the course of HIV-1 infection, transmission is typically established by a single donor viral variant. Recent studies now provide insight into the phenotypic properties influencing this selection process at transmission, including the contribution of resistance to type I interferons.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400691PMC
http://dx.doi.org/10.1016/j.tim.2017.02.010DOI Listing

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