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Automatic Optical Path Alignment Method for Optical Biological Microscope.
Sensors (Basel)
December 2024
Guangxi Key Laboratory of Machine Vision and Intelligent Control, Wuzhou University, Wuzhou 543000, China.
A high-quality optical path alignment is essential for achieving superior image quality in optical biological microscope (OBM) systems. The traditional automatic alignment methods for OBMs rely heavily on complex masker-detection techniques. This paper introduces an innovative, image-sensor-based optical path alignment approach designed for low-power objective (specifically 4×) automatic OBMs.
View Article and Find Full Text PDFNationwide population-based infection- and vaccine-induced SARS-CoV-2 antibody seroprevalence in Germany in autumn/winter 2021/2022.
Euro Surveill
January 2025
RKI-SOEP-2 Study Group is acknowledged at the end of the article.
BackgroundThe first Corona Monitoring Nationwide (RKI-SOEP) study (October 2020-February 2021) found a low pre-vaccine SARS-CoV-2 antibody seroprevalence (2.1%) in the German adult population (≥ 18 years).AimThe objective of this second RKI-SOEP (RKI-SOEP-2) study in November 2021-March 2022 was to estimate the prevalence of SARS-CoV-2-specific anti-spike and/or anti-nucleocapsid (anti-N) IgG antibodies (combined seroprevalence), past infection based on infection-induced seroprevalence (anti-N), and basic immunisation (at least two antigen contacts through vaccination or infection) in individuals aged ≥ 14 years.
View Article and Find Full Text PDFSpatial transcriptomic analysis reveals significant differences in tumor microenvironment in HPV-dependent and HPV-independent vulvar squamous cell carcinoma.
Gynecol Oncol
January 2025
Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, UK. Electronic address:
Objective: Vulvar squamous cell carcinoma (VSCC) can be either HPV-dependent (HPVd) or HPV-independent (HPVi). HPVd VSCC typically occurs in younger women, has a more favorable prognosis, and develops from high-grade squamous intraepithelial lesions (HSIL). HPVi VSCC predominantly affects older women and arises within areas of chronic inflammation, particularly lichen sclerosis (LS).
View Article and Find Full Text PDFTröger's base-embedded macrocycles with chirality.
Chem Commun (Camb)
January 2025
State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China.
The birth and development of supramolecular chemistry have heralded a new era, where macrocycles have become an irreplaceable research tool. Therefore, the construction of novel macrocycles has become a hot spot. Tröger's base (TB), as a fragment with both rigidity and chirality, promises tremendous potential in the realm of supramolecular chemistry, and its unique properties continue to motivate researchers to explore its inclusion in macrocycles.
View Article and Find Full Text PDFFrequency-domain thermoreflectance with beam offset without the spot distortion for accurate thermal conductivity measurement of anisotropic materials.
Rev Sci Instrum
January 2025
Department of Micro Engineering, Graduate School of Engineering, Kyoto University, Kyotodaigaku-Katsura C3, Nishikyo-ku, Kyoto 615-8540, Japan.
The measurement of thermal conductivities of anisotropic materials and atomically thin films is pivotal for the thermal design of next-generation electronic devices. Frequency-domain thermoreflectance (FDTR) is a pump-probe technique that is known for its accurate and straightforward approach to determining thermal conductivity and stands out as one of the most effective methodologies. Existing research has focused on advancing a measurement system that incorporates beam-offset FDTR.
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