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Combination of fruquintinib with venetoclax for the treatment of colorectal cancer.
Oncol Res
December 2024
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Background: As a novel blocker of vascular endothelial growth factor receptor (VEGFR), fruquintinib has been approved for treating colorectal cancer (CRC). However, its dosage and therapeutic efficacy are limited by its widespread adverse reactions. Venetoclax, recognized as the initial inhibitor of B-cell lymphoma protein 2 (BCL2), has shown potential in boosting the effectiveness of immunotherapy against CRC.
View Article and Find Full Text PDFSpatial profiling of the mouse colonic immune landscape associated with colitis and sex.
Commun Biol
November 2024
SciLifeLab, Department of Protein Science, KTH Royal Institute of Technology, Solna, Sweden.
Article Synopsis
- Inflammatory intestinal conditions represent a significant health issue, yet there is a lack of detailed spatial analysis of immune cells in these conditions.
- Researchers utilized the COMET platform to examine immune cell infiltration in mice, analyzing the immune landscape and noting sex-related differences in response to colitis.
- Findings revealed that male mice showed increased B cells and decreased M2-like macrophages in the distal colon, while females had more helper T cells and neutrophils during homeostasis, highlighting the importance of considering sex variations in future studies of intestinal inflammation.
Multi-omics analysis of the biological function of the VEGF family in colon adenocarcinoma.
Funct Integr Genomics
November 2024
Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing, China.
The vascular endothelial growth factor (VEGF) family plays a crucial role in cancer progression, but the prognostic significance and biological functions of VEGF family members in colon adenocarcinoma (COAD) remain unclear. Using data from The Cancer Genome Atlas, Gene Expression Omnibus, Gene Set Cancer Analysis, cBioPortal, GeneMANIA, String, MethSurv and starBase database, we identified vascular endothelial growth factor B (VEGFB) as a key gene associated with COAD prognosis, with its abnormal expression linked to methylation dysregulation. In vitro experiments confirmed VEGFB expression was significantly higher in colon cancer tissues compared to normal tissues, as shown by Real-time quantitative PCR and immunohistochemistry.
View Article and Find Full Text PDFDietary ω-3 Fatty Acids Mitigate Intestinal Barrier Integrity Alterations in Mice Fed a High-Fat Diet: Implications for Pancreatic Carcinogenesis.
J Nutr
November 2024
Department of Nutrition, University of California, Davis, CA, United States; Department of Environmental Toxicology, University of California, Davis, CA, United States. Electronic address:
Background: Although body fatness is a recognized risk factor for pancreatic ductal adenocarcinoma (PDAC), the underlying mechanisms of how fat composition affects pancreatic carcinogenesis are poorly understood. High-fat diets (HFDs) can disrupt intestinal barrier function, potentially accelerating carcinogenesis. Omega-3 (ω-3) polyunsaturated fatty acids (FAs) have anti-inflammatory properties and help preserve intestinal integrity.
View Article and Find Full Text PDFUltrasound and Microbubble-Induced Reduction of Functional Vasculature Depends on the Microbubble, Tumor Type and Time After Treatment.
Ultrasound Med Biol
January 2025
Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway.
Objective: Ultrasound in combination with microbubbles can enhance accumulation and improve the distribution of various therapeutic agents in tumor tissue, leading to improved efficacy. Understanding the impact of treatment on the tumor microenvironment, concurrently with how microenvironment attributes affect treatment outcome, will be important for selecting appropriate patient cohorts in future clinical trials. The main aim of this work was to investigate the influence of ultrasound and microbubbles on the functional vasculature of cancer tissue.
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