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Neurological Disorders and Use of Healthcare Services After Enteroviral Meningitis in Childhood: A Nationwide, Population-Based Cohort Study.
J Pediatric Infect Dis Soc
February 2025
Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Background: Nervous system infections are associated with long-term risks of neurological disorders and healthcare service utilization, but little data exist on the long-term risks of enteroviral meningitis in childhood.
Methods: We performed a population-based, nationwide registry-based matched cohort study (1997-2021). We included 925 children with enteroviral meningitis aged <17 years, a comparison cohort, and a cohort of siblings of all individuals.
Enterovirus and Parechovirus Neurologic Infections in Children: Clinical Presentations and Neuropathogenesis.
J Pediatric Infect Dis Soc
January 2025
Sections of Hospital Medicine and Pediatric Infectious Diseases, University of Colorado, Aurora, CO, USA.
Enteroviruses (EVs) and parechoviruses (PeVs) are common pathogens of childhood. Enteroviral infections cause a range of clinical syndromes from mild illness to neurologic manifestations of meningitis, encephalitis, and acute flaccid myelitis. Disease manifestations are driven by a combination of viral replication and host immune response.
View Article and Find Full Text PDFMolecular Analysis of Coxsackievirus B2 Associated With Severe Symptoms of the Central Nervous System.
J Med Virol
November 2024
Central Virology Laboratory, Public Health Services, Ministry of Health and Sheba Medical Center, Ramat-Gan, Israel.
Coxsackievirus B2 (CVB2) is a member of the enterovirus group known to induce a spectrum of illnesses, from mild to severe. In the summer of 2022, an unusual outbreak of enteroviral central nervous system (CNS) infections occurred that was attributed to CVB2. Cerebrospinal fluid (CSF) samples collected from patients in 2015-2022 were tested for enterovirus via RT-PCR, followed by Sanger sequencing for positive cases.
View Article and Find Full Text PDFClinical Significance of Lumbar Puncture in Children with First Febrile Seizures.
Iran J Child Neurol
September 2024
Department of Pediatrics, College of Medicine, Kyung Hee University, Seoul, Korea.
Objectives: To evaluate the need for lumbar puncture (LP) in children aged 6 to 60 months experiencing their first febrile seizure, regardless of seizure type, and to determine if LP is particularly beneficial for those under 12 months old.
Materials & Methods: In this retrospective study, data from 253 children who presented with first febrile seizure were analyzed. All patients in this study underwent LP and were divided into two groups based on their cerebrospinal fluid (CSF) results: non-pleocytosis and pleocytosis.
Israeli neonatal herpes simplex infection: Unique epidemiology and clinical profile.
J Med Virol
September 2024
Pediatric Infectious diseases Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
Article Synopsis
- A study conducted on Israeli neonatal herpes simplex virus (NHSV) infection collected data from 2015 to 2022, comparing clinical characteristics of NHSV patients with those suffering from neonatal enteroviral meningitis (NEM).
- The results showed an NHSV incidence of 5.9 per 100,000 live births, with notable demographics suggesting that horizontal transmission was linked to practices like ritual circumcision.
- NHSV patients presented unique symptoms such as a lower incidence of fever and irritability but showed a tendency for rashes and seizures, marking a distinct clinical profile compared to NEM, which can help guide treatment approaches for infected newborns.
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